ArticleApplied and environmental microbiology2012
Oxidative stress tolerance, adenylate cyclase, and autophagy are key players in the chronological life span of Saccharomyces cerevisiae during winemaking.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Physiological and Molecular Characterization of an Oxidative Stress-ResistantFrontiers in microbiology · 2022Article
- mRNA profile provides novel insights into stress adaptation in mud crab megalopa, Scylla paramamosain after salinity stress.BMC genomics · 2020Article
- Saccharomyces cerevisiae nutrient signaling pathways show an unexpected early activation pattern during winemaking.Microbial cell factories · 2020Article
- Role ofFrontiers in bioengineering and biotechnology · 2020Article
- Roles for Stress Response and Cell Wall Biosynthesis Pathways in Caspofungin Tolerance inGenetics · 2019Article
- Saccharomyces cerevisiae Cytosolic Thioredoxins Control Glycolysis, Lipid Metabolism, and Protein Biosynthesis under Wine-Making Conditions.Applied and environmental microbiology · 2019Article
- Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes.Scientific reports · 2018Article
- Herbicide glufosinate inhibits yeast growth and extends longevity during wine fermentation.Scientific reports · 2017Article
- A molecular genetic toolbox forBiotechnology for biofuels · 2017Article
- Interplay among Gcn5, Sch9 and mitochondria during chronological aging of wine yeast is dependent on growth conditions.PloS one · 2015Article
- Enhancement of ethanol fermentation in Saccharomyces cerevisiae sake yeast by disrupting mitophagy function.Applied and environmental microbiology · 2014Article
- Saccharomyces cerevisiae KNU5377 stress response during high-temperature ethanol fermentation.Molecules and cells · 2013Article
- Genetic manipulation of longevity-related genes as a tool to regulate yeast life span and metabolite production during winemaking.Microbial cell factories · 2013Article
- Two-carbon metabolites, polyphenols and vitamins influence yeast chronological life span in winemaking conditions.Microbial cell factories · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most grape juice fermentation takes place when yeast cells are in a nondividing state called the stationary phase. Under such circumstances, we aimed to identify the genetic determinants controlling longevity, known as the chronological life span. We identified commercial strains with both short (EC1118) and long (CSM) life spans in laboratory growth medium and compared them under diverse conditions. Strain CSM shows better tolerance to stresses, including oxidative stress, in the stationary phase. This is reflected during winemaking, when this strain has an increased maximum life span. Compared to EC1118, CSM overexpresses a mitochondrial rhodanese gene-like gene, RDL2, whose deletion leads to increased reactive oxygen species production at the end of fermentation and a correlative loss of viability at this point. EC1118 shows faster growth and higher expression of glycolytic genes, and this is related to greater PKA activity due to the upregulation of the adenylate cyclase gene. This phenotype has been linked to the presence of a δ element in its promoter, whose removal increases the life span. Finally, EC1118 exhibits a higher level of protein degradation by autophagy, which might help achieve fast growth at the expense of cellular structures and may be relevant for long-term survival under winemaking conditions.
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