ReviewCurrent opinion in endocrinology, diabetes, and obesity2012
What causes the insulin resistance underlying obesity?
Review in Current opinion in endocrinology, diabetes, and obesity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 268 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
268 citing papers in PubMed, 6 syntheses or guidelines pooled it, 538 citations in OpenAlex.
- Physical Inactivity and Metabolic Syndrome in the United Arab Emirates: A Systematic Review and Meta-analysis of Parallel Epidemics.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- The association between prediabetes and obstructive sleep apnea syndrome: a meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Body Composition and Prostate Cancer Risk: A Systematic Review of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- The Effects of COVID-19 Lockdown on Glycaemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- The effect of overweight/obesity on diastolic function in children and adolescents: A meta-analysis.Clinical obesity · 2021Pooled it
- Intermittent fasting for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2021Pooled it
- Calanus Oil and Lifestyle Interventions Improve Glucose Homeostasis in Obese Subjects with Insulin Resistance.Marine drugs · 2025Trial
- Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults.Lipids in health and disease · 2021Trial
- Trial
- Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial.Lipids in health and disease · 2019Trial
- Navigating the potential of algal peptides: health effects, market applications, and scientific challenges.Annals of medicine · 2026Review
- Anthropometric factors, physical activity, and the risk of soft tissue sarcoma: a case-control study.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026Article
- Anthropometric traits, metabolic biomarkers, and pancreatic cancer risk: a causal mediation analysis in UK Biobank.British journal of cancer · 2026Article
- Metabolic Syndrome and Male Infertility: The Role of Obesity and Chronic Inflammation.Biomedicines · 2026Review
- Role of systemic and epicardial adipose tissue in cardiometabolic disease.Nature reviews. Cardiology · 2026Review
- Adiposity-based obesity classification and cardiometabolic and kidney outcomes: a longitudinal UK Biobank analysis.EBioMedicine · 2026Article
- The cardiometabolic index and miR-29a as related biomarkers for insulin resistance and dysglycemia in adults: insights from the KERCADRS study.Scientific reports · 2026Article
- Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation.Biogerontology · 2026Review
- Use of C-peptide and homeostasis model assessment of insulin resistance to assess insulin resistance in dogs.Journal of veterinary internal medicine · 2026Article
- Adipose Tissue-Targeted Delivery of Rosiglitazone With Iron Oxide Nanoparticles Ameliorates Insulin Resistance in Male Mice.Obesity (Silver Spring, Md.) · 2026Article
208 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewThe association between obesity and insulin resistance is an area of much interest and enormous public health impact, with hundreds of articles being published in the last year focused on the possible mechanisms that underlie this association. The purpose to this review is to highlight some of the key recent literature with emphasis on emerging concepts. RECENT
findingsThe specific link between visceral adipose tissue accumulation and insulin resistance continues to be discerned. Visceral adiposity is correlated with accumulation of excess lipid in liver, and results in cell autonomous impairment in insulin signaling. Visceral adipose tissue is also prone to inflammation and inflammatory cytokine production, which also contribute to impairment in insulin signaling. The expansion of visceral adipose tissue and excess lipid accumulation in liver and muscle may result from limited expandability of subcutaneous adipose tissue, due to the properties of its extracellular matrix and capacity for capillary growth. SUMMARY: Recent studies underscore the need to better understand the mechanisms linking visceral adiposity with liver fat accumulation, the mechanisms by which ectopic fat accumulation cause insulin resistance, and the mechanisms by which the size of adipose tissue depots is determined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.