ReviewJournal of innate immunity2012
Innate immune functions of macrophage subpopulations in the spleen.
Review in Journal of innate immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
106 citing papers in PubMed, 210 citations in OpenAlex.
- Guiding off-target nanomedicine repurposing in spleen for cancer immunotherapy.Journal of nanobiotechnology · 2026Article
- Immunometabolic Organ Crosstalk in Heart Failure with Preserved Ejection Fraction: The Role of Dietary Patterns in Obesity-Related Inflammation.Nutrients · 2026Review
- Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen.bioRxiv : the preprint server for biology · 2026Article
- The Emerging Role of Transcription Factor Spi-C in Macrophage Biology and Inflammatory Pathogenesis.International journal of molecular sciences · 2026Review
- Article
- Tumor-Induced Rewiring of Splenic Niches: from Immune Organ to Cancer Accomplice.International journal of biological sciences · 2026Review
- Comparative omics analysis of the impact ofVirulence · 2025Article
- Strain-Specific Safety Evaluation ofFood science & nutrition · 2025Article
- Article
- Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity.Immunity, inflammation and disease · 2025Review
- Long-term intravital subcellular imaging with confocal scanning light-field microscopy.Nature biotechnology · 2025Article
- Circadian rhythm, epigenetics and disease interaction.Global medical genetics · 2025Review
- CAR-T therapy toxicities: the importance of macrophages in their development and possible targets for their management.Discover oncology · 2025Review
- Targeted spleen modulation: a novel strategy for next-generation disease immunotherapy.Theranostics · 2025Review
- Macrophage subtypes and pathways in autoimmune interstitial lung diseases: potential therapeutic targets.Frontiers in immunology · 2025Article
- Comprehensive review of macrophage models: primary cells and immortalized lines across species.Frontiers in immunology · 2025Review
- Effects of maternal-offspring supplementation of probiotics and synbiotics on the immunity of offspring Bama mini-pigs.Frontiers in immunology · 2025Article
- The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver.Biomolecules · 2024Review
- Article
- Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the different compartments of the spleen, macrophage populations can be found that have different functions depending on their localization. In the lymphoid compartment of the spleen, the white pulp, macrophages are in essence similar to populations found in lymph nodes and other organized secondary lymphoid organs. In the red pulp, large populations of classical scavenger macrophages are found that, in addition to scavenging blood-borne debris, are involved in iron recycling by phagocytosis of effete red blood cells. The most conspicuous macrophage populations of the spleen are located in the marginal zone. Strategically positioned in the bloodstream and adorned with unique sets of pattern recognition receptors, they play an important role in host defense by bridging the innate and adaptive immune systems. In this review, the various macrophage subsets of the spleen are described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.