ArticleDiabetologia2012
Diabetes aggravates acute pancreatitis and inhibits pancreas regeneration in mice.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Preexisting Diabetes Elevates Risk of Local and Systemic Complications in Acute Pancreatitis: Systematic Review and Meta-analysis.Pancreas · 2018Pooled it
- Risk spectrum of admission HbA1c levels and acute pancreatitis severity: a real-world study revealing younger high-risk populations and nonlinear associations.Annals of medicine · 2026Article
- Modulation of Pancreatic Activity by Ghrelin and Its Potential Effects on Acute Pancreatitis.Digestive diseases and sciences · 2026Review
- Fluid resuscitation in the early management of acute pancreatitis: a five-year retrospective observational study.World journal of emergency medicine · 2026Article
- Mechanistic insights into how intrapancreatic fat deposition drives the development of acute pancreatitis.International journal of biological sciences · 2026Review
- Review
- Long-Term All-Cause Mortality After Acute Pancreatitis: Median 7-Year Follow-Up.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Endocrine-exocrine miR-503-322 drives aging-associated pancreatitis via targeting MKNK1 in acinar cells.Nature communications · 2025Article
- Risk Assessment for Gastrointestinal Diseases via Clinical Dimension and Genome-Wide Polygenic Risk Scores of Type 2 Diabetes: A Population-Based Cohort Study.Diabetes care · 2024Article
- Acute Pancreatitis and Type 2 Diabetes Mellitus: The Chicken-Egg Paradox-A Seven-Year Experience of a Large Tertiary Center.Journal of clinical medicine · 2024Article
- Clinical Outcomes of Diabetes Mellitus on Moderately Severe Acute Pancreatitis and Severe Acute Pancreatitis.Journal of inflammation research · 2024Article
- Association between time in range 70-180 mg/dl in early stage and severity with in patients acute pancreatitis.BMC endocrine disorders · 2023Article
- The role of high serum triglyceride levels on pancreatic necrosis development and related complications.BMC gastroenterology · 2023Article
- Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis.Clinical science (London, England : 1979) · 2022Article
- Article
- The relationship between pre-existing diabetes mellitus and the severity of acute pancreatitis: Report from a large international registry.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Article
- Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps.Nature communications · 2021Article
- Fibroblast growth factor 21: a novel long-acting hypoglycemic drug for canine diabetes.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Analysis of Pain and Analgesia Protocols in Acute Cerulein-Induced Pancreatitis in Male C57BL/6 Mice.Frontiers in physiology · 2021Article
- Prognostic Value of Glucose-to-Lymphocyte Ratio in Critically Ill Patients with Acute Pancreatitis.International journal of general medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIt is well established that acute pancreatitis often causes diabetes and that a high blood glucose level associated with pancreatitis is a marker of poor prognosis. The aim of this study was to evaluate if diabetes merely reflects the severity of pancreatitis or whether it can also aggravate the progression of this disease in a vicious circle.
methodsReversible acute oedematous pancreatitis was induced in untreated and streptozotocin-treated diabetic mice by injection of cerulein. Progression of pancreatitis was studied by immunohistochemistry, ELISA and various other enzyme assays. The production of regenerating islet-derived 3β (REG3β) was determined by western blot and immunohistochemistry.
resultsWhile cerulein treatment in non-diabetic mice resulted in acute pancreatitis followed by regeneration of the pancreas within 7 days, diabetes aggravated pancreatitis, inhibited the regeneration of the exocrine tissue and led to strong atrophy of the pancreas. The aggravation of pancreatitis by diabetes was characterised by decreased production of the anti-inflammatory protein REG3β, increased inflammation, augmented oedema formation and increased cell death during the acute phase of pancreatitis (p < 0.05). During the regenerative phase, diabetes augmented inflammation, increased cell death, reduced acinar cell expansion and increased the expansion of duct as well as interstitial cells, resulting in the formation of tubular complexes (p < 0.05). Administration of insulin reversed the observed phenotype in diabetic mice. CONCLUSIONS/
interpretationDiabetes aggravates acute pancreatitis and suppresses regeneration of the exocrine tissue. Thus, diabetes is not just a concomitant phenomenon of pancreatitis, but can have a fundamental influence on the progression of acute pancreatitis.
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Registered trials
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