ArticleDevelopment genes and evolution2012
Morphological and molecular development of the eyes during embryogenesis of the freshwater planarian Schmidtea polychroa.
Article in Development genes and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- A single-cell atlas of the bobtail squid visual and nervous system highlights molecular principles of convergent evolution.Nature ecology & evolution · 2025Article
- Developmental onset of planarian whole-body regeneration depends on axis reset.Current biology : CB · 2025Article
- Reduced adult stem cell fate specification led to eye reduction in cave planarians.Nature communications · 2025Article
- Convergent evolution of the sensory pits in and within flatworms.BMC biology · 2023Article
- Emergence of novel genomic regulatory regions associated with light-organ development in the bobtail squid.iScience · 2023Article
- Evolution and development of complex eyes: a celebration of diversity.Development (Cambridge, England) · 2020Review
- The planarianThe Journal of experimental biology · 2017Article
- Article
- Ancestral and novel roles of Pax family genes in mollusks.BMC evolutionary biology · 2017Article
- Eye Development inFrontiers in physiology · 2017Article
- Temporal regulation of planarian eye regeneration.Regeneration (Oxford, England) · 2016Article
- Mesodermal gene expression during the embryonic and larval development of the articulate brachiopod Terebratalia transversa.EvoDevo · 2015Article
- Article
- Old cell, new trick? Cnidocytes as a model for the evolution of novelty.Integrative and comparative biology · 2014Review
- Eye-specification genes in the bacterial light organ of the bobtail squid Euprymna scolopes, and their expression in response to symbiont cues.Mechanisms of development · 2014Article
- The planarian regeneration transcriptome reveals a shared but temporally shifted regulatory program between opposing head and tail scenarios.BMC genomics · 2013Article
- The urbilaterian brain revisited: novel insights into old questions from new flatworm clades.Development genes and evolution · 2013Article
- Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration.Cell reports · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoreception is one of the most primitive sensory functions in metazoans. Despite the diversity of forms and components of metazoan eyes, many studies have demonstrated the existence of a common cellular and molecular basis for their development. Genes like pax6, sine oculis, eyes absent, dachshund, otx, Rx and atonal are known to be associated with the specification and development of the eyes. In planarians, sine oculis, eyes absent and otxA play an essential role during the formation of the eye after decapitation, whereas pax6, considered by many authors as a master control gene for eye formation, does not seem to be involved in adult eye regeneration. Whether this is a peculiarity of adult planarians or, on the contrary, is also found in embryogenesis remains unknown. Herein, we characterize embryonic eye development in the planarian species Schmidtea polychroa using histological sections and molecular markers. Additionally, we analyse the expression pattern of the pax6-sine oculis-eyes absent-dachshund network, and the genes Rx, otxA, otxB and atonal. We demonstrate that eye formation in planarian embryos shows great similarities to adult eye regeneration, both at the cellular and molecular level. We thus conclude that planarian eyes exhibit divergent molecular patterning mechanisms compared to the prototypic ancestral metazoan eye.
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