ReviewJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2012
Coping with physiological oxidative stress: a review of antioxidant strategies in seals.
Review in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
- Accumulation of CO2 limits energy gain in freely diving grey seals.The Journal of experimental biology · 2026Article
- Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?Diabetologia · 2026Review
- Phylogenomic Approaches to Study Adaptive Evolution in Mammals: From Aging to Aquatic Lifestyles.Annual review of genetics · 2025Review
- Prolonged fasting and glucocorticoid exposure drive dynamic DNA methylation in northern elephant seals.The Journal of experimental biology · 2025Article
- Assessing Bottlenose Dolphins' (Animals : an open access journal from MDPI · 2025Article
- Species-specific physiological status in seabirds: insights from integrating oxidative stress measurements and biologging.Frontiers in physiology · 2025Article
- Lessons in immune adaptations to hypoxia revealed by comparative and evolutionary physiology.BMC biology · 2023Article
- Total Mercury, Total Selenium, and Monomethylmercury Relationships in Multiple Age Cohorts and Tissues of Steller Sea Lions (Eumetopias jubatus).Environmental toxicology and chemistry · 2022Article
- The Antarctic Weddell seal genome reveals evidence of selection on cardiovascular phenotype and lipid handling.Communications biology · 2022Article
- Time Domains of Hypoxia Responses and -Omics Insights.Frontiers in physiology · 2022Review
- Elevated antioxidant defence in the brain of deep-diving pinnipeds.Frontiers in physiology · 2022Article
- Cardiac hypoxic resistance and decreasing lactate during maximum apnea in elite breath hold divers.Scientific reports · 2021Article
- Extreme Hypoxia Causing Brady-Arrythmias During Apnea in Elite Breath-Hold Divers.Frontiers in physiology · 2021Article
- Article
- Biomimetics provides lessons from nature for contemporary ways to improve human health.Journal of clinical and translational science · 2021Review
- Genomewide analysis of sperm whale E2 ubiquitin conjugating enzyme genes.Journal of genetics · 2021Article
- Proteomics in Non-model Organisms: A New Analytical Frontier.Journal of proteome research · 2020Article
- Induced pluripotent stem cells as a tool for comparative physiology: lessons from the thirteen-lined ground squirrel.The Journal of experimental biology · 2019Review
- Antibacterial and antioxidant effects ofJournal of traditional and complementary medicine · 2019Article
- Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
While diving, seals are exposed to apnea-induced hypoxemia and repetitive cycles of ischemia/reperfusion. While on land, seals experience sleep apnea, as well as prolonged periods of food and water deprivation. Prolonged fasting, sleep apnea, hypoxemia and ischemia/reperfusion increase oxidant production and oxidative stress in terrestrial mammals. In seals, however, neither prolonged fasting nor apnea-induced hypoxemia or ischemia/reperfusion increase systemic or local oxidative damage. The strategies seals evolved to cope with increased oxidant production are reviewed in the present manuscript. Among these strategies, high antioxidant capacity and the oxidant-mediated activation of hormetic responses against hypoxia and oxidative stress are discussed. In addition to expanding our knowledge of the evolution of antioxidant defenses and adaptive responses to oxidative stress, understanding the mechanisms that naturally allow mammals to avoid oxidative damage has the potential to advance our knowledge of oxidative stress-induced pathologies and to enhance the translative value of biomedical therapies in the long term.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.