Trial reportObesity (Silver Spring, Md.)2012
Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the Look AHEAD Study.
Trial report in Obesity (Silver Spring, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Determinants of weight loss maintenance: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Pooled it
- Baseline characteristics associated with different BMI trajectories in weight loss trials: a case for better targeting of interventions.European journal of clinical nutrition · 2016Pooled it
- Effect Sizes and Primary Outcomes in Large-Budget, Cardiovascular-Related Behavioral Randomized Controlled Trials Funded by NIH Since 1980.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016Pooled it
- Metabolites and diabetes remission after weight loss.Nutrition & diabetes · 2021Trial
- The association between weight maintenance and session-by-session diet adherence, weight loss and weight-loss satisfaction.Eating and weight disorders : EWD · 2020Trial
- Trial
- Markers of dietary protein intake are associated with successful weight loss in the POUNDS Lost trial.Clinical obesity · 2017Trial
- Cardiovascular Events in a Physical Activity Intervention Compared With a Successful Aging Intervention: The LIFE Study Randomized Trial.JAMA cardiology · 2016Trial
- Longitudinal Weight Loss Patterns and their Behavioral and Demographic Associations.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016Trial
- Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.PloS one · 2016Trial
- Long-term changes in cardiovascular risk markers during administration of exenatide twice daily or glimepiride: results from the European exenatide study.Cardiovascular diabetology · 2015 · on this mapTrial
- Application of Latent Class Analysis to Identify Behavioral Patterns of Response to Behavioral Lifestyle Interventions in Overweight and Obese Adults.International journal of behavioral medicine · 2015Trial
- Short-term weight loss patterns, baseline predictors, and longer-term follow-up within a randomized controlled trial.Obesity (Silver Spring, Md.) · 2014Trial
- SisterTalk: final results of a culturally tailored cable television delivered weight control program for Black women.The international journal of behavioral nutrition and physical activity · 2013Trial
- Multimodal (Bio)Markers and Risk of Obesity - A Comprehensive Scoping Review.Advances in nutrition (Bethesda, Md.) · 2026Article
- Weight Trajectory Impacts Risk for 10 Distinct Cardiometabolic Diseases.The Journal of clinical endocrinology and metabolism · 2025Article
- Weight Loss Trajectories and Short-Term Prediction in an Online Weight Management Program.Nutrients · 2024Article
- The relation between excess adiposity and breast cancer in women: Clinical implications and management.Critical reviews in oncology/hematology · 2024Review
- Weight loss to disrupt type 2 diabetes.Diabetology international · 2023Review
- Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation.BMC medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
This article provides an assessment of the associations that weight-loss patterns during the first year of an intensive lifestyle intervention have with 4-year maintenance and health outcomes. Two components described patterns of weight change during the first year of intervention: one reflected the typical pattern of weight loss over the 12 months, but distinguished those who lost larger amounts across the monthly intervals from those who lost less. The second component reflected the weight change trajectory, and distinguished a pattern of initial weight loss followed by regain vs. a more sustained pattern of weight loss. Two thousand four hundred and thirty eight individuals aged 45-76 years with type 2 diabetes mellitus, who enrolled in the weight-loss intervention of a randomized clinical trial, were assigned scores according to how their weight losses reflected these patterns. Relationships these scores had with weight losses and health outcomes (glycosolated hemoglobin--hemoglobin A1c (HbA1c); systolic blood pressure, high-density lipoprotein (HDL)-cholesterol, and triglycerides) over 4 years were described. When compared to those with lower scores on the two components, both individuals who had larger month-to-month weight losses in year 1 and whose weight loss was more sustained during the first year had better maintenance of weight loss over 4 years, independent of characteristics traditionally linked to weight loss success (P < 0.001). While relationships with year 4 weight loss were stronger, the pattern of larger monthly weight loss during year 1 was also independently predictive of year 4 levels of HbA1c, HDL-cholesterol, and systolic blood pressure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.