ArticleNeurotoxicology2012
FMRI reveals abnormal central processing of sensory and pain stimuli in ill Gulf War veterans.
Article in Neurotoxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Meta-analysis of self-reported health symptoms in 1990-1991 Gulf War and Gulf War-era veterans.BMJ open · 2018Pooled it
- Influence of pain anticipation on brain activity and pain perception in Gulf War Veterans with chronic musculoskeletal pain.Psychophysiology · 2019Trial
- 16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomized controlled trial.Frontiers in neuroscience · 2025Article
- Comprehensive examination of resting state fMRI connectomics yields new insights into brain function deficits in Gulf War illness after accounting for heterogeneity in brain impairment across the ill veteran population.Neuroimage. Reports · 2024Article
- Review
- Longitudinal evaluation of structural brain alterations in two established mouse models of Gulf War Illness.Frontiers in neuroscience · 2024Article
- Study protocol for a revised randomized trial: Remotely delivered Tai Chi and wellness for Gulf War illness.Contemporary clinical trials · 2023Article
- Evaluation of delayed LNFPIII treatment initiation protocol on improving long-term behavioral and neuroinflammatory pathology in a mouse model of Gulf War Illness.Brain, behavior, & immunity - health · 2022Article
- Dry Eye Symptoms and Signs in US Veterans With Gulf War Illness.American journal of ophthalmology · 2022Article
- Evaluation of a Gene-Environment Interaction ofEnvironmental health perspectives · 2022Article
- Gulf War veterans exhibit broadband sleep EEG power reductions in regions overlying the frontal lobe.Life sciences · 2021Article
- Nociceptive stress interferes with neural processing of cognitive stimuli in Gulf War Veterans with chronic musculoskeletal pain.Life sciences · 2021Article
- In-vivo imaging of neuroinflammation in veterans with Gulf War illness.Brain, behavior, and immunity · 2020Article
- Review
- The prevalence of headaches, pain, and other associated symptoms in different Persian Gulf deployment periods and deployment durations.SAGE open medicine · 2019Article
- Subcortical brain atrophy in Gulf War Illness.Experimental brain research · 2017Article
- A Magnetoencephalographic (MEG) Study of Gulf War Illness (GWI).EBioMedicine · 2016Article
- Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment.Cortex; a journal devoted to the study of the nervous system and behavior · 2016Review
- Using gene expression signatures to identify novel treatment strategies in gulf war illness.BMC medical genomics · 2015Article
- Central Executive Dysfunction and Deferred Prefrontal Processing in Veterans with Gulf War Illness.Clinical psychological science : a journal of the Association for Psychological Science · 2014Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Many veterans chronically ill from the 1991 Gulf War exhibit symptoms of altered sensation, including chronic pain. In this study of 55 veterans of a Construction Battalion previously examined in 1995-1996 and 1997-1998, brain activation to innocuous and noxious heat stimuli was assessed in 2008-2009 with a quantitative sensory testing fMRI protocol in control veterans and groups representing three syndrome variants. Testing outside the scanner revealed no significant differences in warm detection or heat pain threshold among the four groups. In the fMRI study, Syndrome 1 and Syndrome 2, but not Syndrome 3, exhibited hypo-activation to innocuous heat and hyper-activation to noxious heat stimuli compared to controls. The results indicate abnormal central processing of sensory and painful stimuli in 2 of 3 variants of Gulf War illness and call for a more comprehensive study with a larger, representative sample of veterans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.