ArticleDevelopmental biology2012
Conditions that influence the response to Fgf during otic placode induction.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear.Developmental biology · 2022Article
- Comparative assessment of Fgf's diverse roles in inner ear development: A zebrafish perspective.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Development and evolution of the vestibular apparatuses of the inner ear.Journal of anatomy · 2021Review
- Research Progress on the Mechanism of Cochlear Hair Cell Regeneration.Frontiers in cellular neuroscience · 2021Article
- Genetic Causes of Inner Ear Anomalies: a Review from the Turkish Study Group for Inner Ear AnomaliesBalkan medical journal · 2019Review
- Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression.PLoS genetics · 2019Article
- sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish.Developmental biology · 2018Article
- sox2 and sox3 Play unique roles in development of hair cells and neurons in the zebrafish inner ear.Developmental biology · 2018Article
- A gene network regulated by FGF signalling during ear development.Scientific reports · 2017Article
- Recovery of shape and size in a developing organ pair.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cooperative and independent functions of FGF and Wnt signaling during early inner ear development.BMC developmental biology · 2015Article
- The role of foxi family transcription factors in the development of the ear and jaw.Current topics in developmental biology · 2015Review
- Compensatory regulation of the size of the inner ear in response to excess induction of otic progenitors by fibroblast growth factor signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Mesodermal Fgf10b cooperates with other fibroblast growth factors during induction of otic and epibranchial placodes in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Establishing the pre-placodal region and breaking it into placodes with distinct identities.Developmental biology · 2014Review
- Sp8 regulates inner ear development.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A gene network that coordinates preplacodal competence and neural crest specification in zebrafish.Developmental biology · 2013Article
- Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation.Development (Cambridge, England) · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Despite the vital importance of Fgf for otic induction, previous attempts to study otic induction through Fgf misexpression have yielded widely varying and contradictory results. There are also discrepancies regarding the ability of Fgf to induce otic tissue in ectopic locations, raising questions about the sufficiency of Fgf and the degree to which other local factors enhance or restrict otic potential. Using heat shock-inducible transgenes to misexpress Fgf3 or Fgf8 in zebrafish, we found that the stage, distribution and level of misexpression strongly influence the response to Fgf. Fgf misexpression during gastrulation can inhibit or promote otic development, depending on context, whereas misexpression after gastrulation leads to expansion of otic markers throughout preplacodal ectoderm surrounding the head. Elevated Fgf also expands expression of the putative competence factor Foxi1, which is required for Fgf to expand other otic markers. Misexpression of downstream factors Pax2a or Pax8 also expands otic markers but cannot bypass the requirement for Fgf or Foxi1. Co-misexpression of Pax2/8 with Fgf8 potentiates formation of ectopic otic vesicles expressing a full range of otic markers. These findings document the variables critically affecting the response to Fgf and clarify the roles of foxi1 and pax2/8 in the otic response.
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Registered trials
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