Evidence map›Paper›PMID 22326668›Full record

ReviewCurrent opinion in cell biology2012

Trafficking to uncharted territory of the nuclear envelope.

Laura T Burns, Susan R Wente

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Phosphatidic acid signaling and function in nuclei.Progress in lipid research · 2024
    Review
  2. Review
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  7. Review
  8. Review
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  11. Mechanisms of ciliary targeting: entering importins and Rabs.Cellular and molecular life sciences : CMLS · 2018
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura T BurnsDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Susan R Wente

Funding

BIOCHEMICAL &CHEMICAL TRAINING FOR CANCER RESEARCHT32CA009582 · NCI · VANDERBILT UNIVERSITY · PI David K Cortez · 1987 to 2026
$8.8M
Molecular Analysis of Nuclear Pore Complex FunctionR37GM051219 · NIGMS · VANDERBILT UNIVERSITY · PI WENTE, SUSAN R. · 2010 to 2019
$5.6M
REGULATION OF NUCLEAR PORE COMPLEX ASSEMBLYR01GM057438 · NIGMS · WASHINGTON UNIVERSITY · PI HETZER, MARTIN W, WENTE, SUSAN R. · 1998 to 2011
$3.5M
MECHANISMS OF GLUTATHIONE S TRANSFERASER01GM051210 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1995 to 1998
–
NCI NIH HHS T32 CA009582NIGMS NIH HHS R01 GM057438NIGMS NIH HHS R01 GM57438NIGMS NIH HHS R37 GM051219NIGMS NIH HHS R37 GM51210
6 · The paper itself

Abstract

The nuclear envelope (NE) in eukaryotic cells serves as the physical barrier between the nucleus and cytoplasm. Until recently, mechanisms for establishing the composition of the inner nuclear membrane (INM) remained uncharted. Current findings uncover multiple pathways for trafficking of integral and peripheral INM proteins. A major route for INM protein transport occurs through the nuclear pore complexes (NPCs) with additional requirements for nuclear localization sequences, transport receptors, and Ran-GTP. Studies also reveal a putative NPC-independent vesicular pathway for NE trafficking. INM perturbations lead to changes in nuclear physiology highlighting the potential human disease impacts of continued NE discoveries.

Indexed as

Protein TransportBiological TransportCell NucleusCytoplasmEukaryotic CellsHumansNuclear EnvelopeNuclear PoreNuclear Pore Complex ProteinsNuclear Pore Complex Proteins

Identifiers

PMID22326668
PMCPMC3518394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.