ArticleJournal of theoretical biology2012
A computational model of the topographic distribution of ventilation in healthy human lungs.
Article in Journal of theoretical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Direct Numerical Simulations of Inhalation in a 23-Generation Lung Model.International journal for numerical methods in biomedical engineering · 2026Article
- Coupled mixed-dimensional multiphase porous media approach for modeling airflow, blood flow, and gas exchange in the human lungs.Biomechanics and modeling in mechanobiology · 2026Article
- Wide-Angle Lung Experiment Segmentation (WALES): Effective quantitative assessment of lung pathology in model systems.Science advances · 2025Article
- Investigation of inert gas washout methods in a new numerical model based on an electrical analogy.Medical & biological engineering & computing · 2025Article
- Forward Computational Modeling of Respiratory Airflow.Applied sciences (Basel, Switzerland) · 2024Article
- Evaluating the role of sex-related structure-function differences on airway aerosol transport and deposition.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Non-local impact of distal airway constrictions on patterns of inhaled particle deposition.Royal Society open science · 2024Article
- The impact of heterogeneity of the air-blood barrier on control of lung extravascular water and alveolar gas exchange.Frontiers in network physiology · 2023Review
- Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure-volume curves.Scientific reports · 2022Article
- Computational lung modelling in respiratory medicine.Journal of the Royal Society, Interface · 2022Review
- Towards a multi-scale computer modeling workflow for simulation of pulmonary ventilation in advanced COVID-19.Computers in biology and medicine · 2022Article
- Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases.Future medicinal chemistry · 2022Review
- Simulating Multi-Scale Pulmonary Vascular Function by Coupling Computational Fluid Dynamics With an Anatomic Network Model.Frontiers in network physiology · 2022Article
- Whole-lung finite-element models for mechanical ventilation and respiratory research applications.Frontiers in physiology · 2022Article
- Bridging the gap between respiratory research and health literacy: an interactive web-based platform.BMJ simulation & technology enhanced learning · 2021Article
- Surfactant-Mediated Airway and Acinar Interactions in a Multi-Scale Model of a Healthy Lung.Frontiers in physiology · 2020Article
- AVATREE: An open-source computational modelling framework modelling Anatomically Valid Airway TREE conformations.PloS one · 2020Article
- Ventilation/Perfusion Matching: Of Myths, Mice, and Men.Physiology (Bethesda, Md.) · 2019Review
- 1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test.PLoS computational biology · 2019Article
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Authors and funding
3 authors.
Funding
Abstract
The topographic distribution of ventilation in the lungs is determined by the interaction of several factors, including lung shape, airway tree geometry, posture, and tissue deformation. Inter-species differences in lung structure-function and technical difficulty in obtaining high resolution imaging of the upright human lung means that it is not straightforward to experimentally determine the contribution of each of these factors to ventilation distribution. We present a mathematical model for predicting the topological distribution of inhaled air in the upright healthy human lung, based on anatomically structured model geometries and biophysical equations for model function. Gravitational deformation of the lung tissue is predicted using a continuum model. Airflow is simulated in anatomically based conducting airways coupled to geometrically simplified terminal acinar units with varying volume-dependent compliances. The predicted ventilation distribution is hence governed by local tissue density and elastic recoil pressure, airway resistance and acinar compliance. Results suggest that there is significant spatial variation in intrinsic tissue properties in the lungs. The model confirms experimental evidence that in the healthy lungs tissue compliance has a far greater effect than airway resistance on the spatial distribution of ventilation, and hence a realistic description of tissue deformation is essential in models of ventilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.