ArticleMolecular cell2012
A DNA 3' phosphatase functions in active DNA demethylation in Arabidopsis.
Article in Molecular cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 95 citations in OpenAlex.
- DNA Methylation Dynamics in Plant Abiotic Stress Response: Mechanisms, Memory, and Breeding Applications.Genes · 2026Review
- Molecular mechanisms and biological functions of active DNA demethylation in plants.Epigenetics & chromatin · 2025Review
- Molecular Mechanisms Underlying the Establishment, Maintenance, and Removal of DNA Methylation in Plants.Annual review of plant biology · 2025Review
- The enzymatic properties of Arabidopsis thaliana DNA polymerase λ suggest a role in base excision repair.Plant molecular biology · 2024Article
- Base Excision DNA Repair in Plants:International journal of molecular sciences · 2023Review
- Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana.BMC plant biology · 2022Article
- Plant DNA Methylation: An Epigenetic Mark in Development, Environmental Interactions, and Evolution.International journal of molecular sciences · 2022Review
- Review
- The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.The Plant cell · 2022Article
- Stress responses and epigenomic instability mark the loss of somatic embryogenesis competence in grapevine.Plant physiology · 2022Article
- Roles of DEMETER in regulating DNA methylation in vegetative tissues and pathogen resistance.Journal of integrative plant biology · 2021Article
- Article
- Dynamics of DNA Methylation and Its Functions in Plant Growth and Development.Frontiers in plant science · 2021Review
- Involvement of MEM1 in DNA demethylation in Arabidopsis.Plant molecular biology · 2020Article
- Active DNA Demethylation in Plants.International journal of molecular sciences · 2019Review
- Diversity and dynamics of DNA methylation: epigenomic resources and tools for crop breeding.Breeding science · 2019Review
- ALBA protein complex reads genic R-loops to maintain genome stability inScience advances · 2019Article
- Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis.PLoS genetics · 2019Article
- DNA Base Excision Repair in Plants: An Unfolding Story With Familiar and Novel Characters.Frontiers in plant science · 2019Review
- APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE Play Overlapping Roles in the Maintenance of Epigenome and Genome Stability.The Plant cell · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
DNA methylation is an important epigenetic mark established by the combined actions of methylation and demethylation reactions. Plants use a base excision repair pathway for active DNA demethylation. After 5-methylcytosine removal, the Arabidopsis DNA glycosylase/lyase ROS1 incises the DNA backbone and part of the product has a single-nucleotide gap flanked by 3'- and 5'-phosphate termini. Here we show that the DNA phosphatase ZDP removes the blocking 3' phosphate, allowing subsequent DNA polymerization and ligation steps needed to complete the repair reactions. ZDP and ROS1 interact in vitro and colocalize in vivo in nucleoplasmic foci. Extracts from zdp mutant plants are unable to complete DNA demethylation in vitro, and the mutations cause DNA hypermethylation and transcriptional silencing of a reporter gene. Genome-wide methylation analysis in zdp mutant plants identified hundreds of hypermethylated endogenous loci. Our results show that ZDP functions downstream of ROS1 in one branch of the active DNA demethylation pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.