ArticleBiophysical journal2012
Exploring the symmetry and mechanism of virus capsid maturation via an ensemble of pathways.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of infection-critical peptide externalization.Biophysical journal · 2026Article
- Theoretical Studies on Assembly, Physical Stability, and Dynamics of Viruses.Sub-cellular biochemistry · 2024Review
- Non-equilibrium virus particle dynamics: Microsecond MD simulations of the complete Flock House virus capsid under different conditions.Journal of structural biology · 2023Article
- Packaging contests between viral RNA molecules and kinetic selectivity.PLoS computational biology · 2022Article
- Atomistic dynamics of a viral infection process: Release of membrane lytic peptides from a non-enveloped virus.Science advances · 2021Article
- Bacteriophage Capsid Modification by Genetic and Chemical Methods.Bioconjugate chemistry · 2021Review
- Physics of viral dynamics.Nature reviews. Physics · 2021Review
- Structural and dynamic asymmetry in icosahedrally symmetric virus capsids.Current opinion in virology · 2020Review
- Simulations of Phage T7 Capsid Expansion Reveal the Role of Molecular Sterics on Dynamics.Viruses · 2020Article
- Viral nanomechanics with a virtual atomic force microscope.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Article
- Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations.Nature communications · 2017Article
- The role of multivalency in the association kinetics of patchy particle complexes.The Journal of chemical physics · 2017Article
- Allosteric Control of Icosahedral Capsid Assembly.The journal of physical chemistry. B · 2016Article
- A Non-Symmetric Reconstruction Technique for Transcriptionally-Active Viral Assemblies.Journal of analytical & molecular techniques · 2015Article
- Stability of Norwalk Virus Capsid Protein Interfaces Evaluated by in Silico Nanoindentation.Frontiers in bioengineering and biotechnology · 2015Article
- Article
- Recent Developments in Molecular Simulation Approaches to Study Spherical Virus Capsids.Molecular simulation · 2014Article
- Collective variable approaches for single molecule flexible fitting and enhanced sampling.Chemical reviews · 2014Review
- pH-induced stability switching of the bacteriophage HK97 maturation pathway.Journal of the American Chemical Society · 2014Article
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3 authors.
Funding
Abstract
Many icosahedral viruses undergo large-scale conformational transitions between icosahedrally symmetric conformations during their life cycles. However, whether icosahedral symmetry is maintained along the transition pathways for this process is unknown. By employing a simplified and directed structure-based potential we compute an ensemble of transition pathways for the maturation transition of bacteriophage HK97. We observe localized symmetry-breaking events, but find that the large-scale displacements are dominated by icosahedrally symmetric deformation modes. We find that all pathways obey a common mechanism characterized by formation of pentameric contacts early in the transition.
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