ArticleBiophysical journal2012
Pattern formation by graded and uniform signals in the early Drosophila embryo.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Global maps of transcription factor properties reveal threshold-based formation of DNA-bound and mobile clusters.Science advances · 2026Article
- Bulk-level maps of pioneer factor binding dynamics during the Drosophila maternal-to-zygotic transition.Development (Cambridge, England) · 2025Article
- Epigenetic inheritance and gene expression regulation in early Drosophila embryos.EMBO reports · 2024Review
- Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in earlyeLife · 2023Article
- Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation.Developmental cell · 2023Article
- Review
- Spatial organization of transcribing loci during early genome activation in Drosophila.Current biology : CB · 2021Article
- Article
- Spatiotemporal control of gene expression boundaries using a feedforward loop.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output.Current biology : CB · 2019Article
- Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs.Nature communications · 2018Article
- Two-Exponential Models of Gene Expression Patterns for Noisy Experimental Data.Journal of computational biology : a journal of computational molecular cell biology · 2018Article
- Relieving the Pressure on Tissue Development.Biophysical journal · 2017Article
- Drosophila poised enhancers are generated during tissue patterning with the help of repression.Genome research · 2017Article
- Genome-wide measurement of spatial expression in patterning mutants ofF1000Research · 2017Article
- Morphogen rules: design principles of gradient-mediated embryo patterning.Development (Cambridge, England) · 2015Review
- Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation.Genome research · 2015Article
- What does it take to evolve an enhancer? A simulation-based study of factors influencing the emergence of combinatorial regulation.Genome biology and evolution · 2015Article
- Response to Nodal morphogen gradient is determined by the kinetics of target gene induction.eLife · 2015Article
- The presence of nuclear cactus in the early Drosophila embryo may extend the dynamic range of the dorsal gradient.PLoS computational biology · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The early Drosophila embryo is patterned by graded distributions of maternal transcription factors. Recent studies revealed that pattern formation by these graded signals depends on uniformly expressed transcriptional activators, such as Zelda. Removal of Zelda influences both the timing and the spatial expression domains for most of the genes controlled by maternal gradients. We demonstrate that some of these patterning defects, which range from temporal delay to loss of expression, can be rationalized with the use of a mathematical model based on cooperative binding of graded and uniform factors. This model makes a number of predictions, which we confirm experimentally by analyzing the expression of short gastrulation (sog), a gene that is controlled by a combination of the Dorsal morphogen gradient and Zelda. The proposed model suggests a general mechanism for the formation of nested gene expression domains, which is a hallmark of tissue patterning by morphogen gradients. According to this mechanism, the differential effects of a morphogen on its target genes can depend on their differential sensitivity to uniform factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.