ArticleBiophysical journal2012
Outer hair cell somatic electromotility in vivo and power transfer to the organ of Corti.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current.Scientific reports · 2024Article
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea.Communications biology · 2024Article
- Interplay between traveling wave propagation and amplification at the apex of the mouse cochlea.Biophysical journal · 2022Article
- A flexible anatomical set of mechanical models for the organ of Corti.Royal Society open science · 2021Article
- Power Dissipation in the Cochlea Can Enhance Frequency Selectivity.Biophysical journal · 2019Article
- The effect of AP-2δ on transcription of the Prestin gene in HEI-OC1 cells upon oxidative stress.Cellular & molecular biology letters · 2019Article
- Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs.Neural plasticity · 2018Article
- Negative membrane capacitance of outer hair cells: electromechanical coupling near resonance.Scientific reports · 2017Article
- Two passive mechanical conditions modulate power generation by the outer hair cells.PLoS computational biology · 2017Article
- Amplification mode differs along the length of the mouse cochlea as revealed by connexin 26 deletion from specific gap junctions.Scientific reports · 2017Article
- Energy Output from a Single Outer Hair Cell.Biophysical journal · 2016Article
- Cochlear Outer-Hair-Cell Power Generation and Viscous Fluid Loss.Scientific reports · 2016Article
- Optogenetic Control of Mouse Outer Hair Cells.Biophysical journal · 2016Article
- Power dissipation in the subtectorial space of the mammalian cochlea is modulated by inner hair cell stereocilia.Biophysical journal · 2015Article
- Article
- Non-uniform distribution of outer hair cell transmembrane potential induced by extracellular electric field.Biophysical journal · 2013Article
- Effects of cochlear loading on the motility of active outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Microdomains shift and rotate in the lateral wall of cochlear outer hair cells.Biophysical journal · 2013Article
- Half-octave shift in mammalian hearing is an epiphenomenon of the cochlear amplifier.PloS one · 2012Article
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2 authors.
Funding
Abstract
The active amplification of sound-induced vibrations in the cochlea, known to be crucial for auditory sensitivity and frequency selectivity, is not well understood. The outer hair cell (OHC) somatic electromotility is a potential mechanism for such amplification. Its effectiveness in vivo is putatively limited by the electrical low-pass filtering of the cell's transmembrane potential. However, the transmembrane potential is an incomplete metric. We propose and estimate two metrics to evaluate the effectiveness of OHC electromotility in vivo. One metric is the OHC electromechanical ratio defined as the amplitude of the ratio of OHC displacement to the change in its transmembrane potential. The in vivo electromechanical ratio is derived from the recently measured in vivo displacements of the reticular lamina and the basilar membrane at the 19 kHz characteristic place in guinea pigs and using a model. The ratio, after accounting for the differences in OHC vibration in situ due to the impedances from the adjacent structures, is in agreement with the literature values of the in vitro electromechanical ratio measured by others. The second and more insightful metric is the OHC somatic power. Our analysis demonstrates that the organ of Corti is nearly optimized to receive maximum somatic power in vivo and that the estimated somatic power could account for the active amplification.
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