Evidence map›Paper›PMID 22325255›Full record

ReviewThe Journal of pediatrics2012

Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?

Nicola J Robertson, Sidhartha Tan, Floris Groenendaal, Frank van Bel, Sandra E Juul, Laura Bennet, Matthew Derrick, Stephen A Back, Raul Chavez Valdez, Frances Northington and 2 more

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 5 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 5 syntheses or guidelines pooled it, 156 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Melatonin for women in pregnancy for neuroprotection of the fetus.The Cochrane database of systematic reviews · 2016
    Pooled it
  4. Magnesium for newborns with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2013
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Review
  12. Perinatal Neuroprotection in Preterm Birth.Geburtshilfe und Frauenheilkunde · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Fetal Brain Development in Congenital Heart Disease.The Canadian journal of cardiology · 2023
    Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Nicola J RobertsonInstitute of Women's Health, University College London, London, UK. n.robertson@ucl.ac.uk
Sidhartha Tan
Floris Groenendaal
Frank van Bel
Sandra E Juul
Laura Bennet
Matthew Derrick
Stephen A Back
Raul Chavez Valdez
Frances Northington
Alistair Jan Gunn
Carina Mallard
NorthShore University HealthSystem · USUniversity Medical Center Utrecht · NLJohns Hopkins Medicine · USJohns Hopkins University · USOregon Health & Science University · USThe Robertson Trust · GBUniversity of Gothenburg · SEUniversity of Washington · US

Funding

Optimizing Neuroprotection Following Perinatal AsphyxiaR01HD052820 · NICHD · UNIVERSITY OF WASHINGTON · PI JUUL, SANDRA E · 2007 to 2011
$3.9M
NICHD NIH HHS R01 HD052820
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AllopurinolBiopterinsErythropoietinHumansInfant, NewbornMelatoninNeuroprotective AgentsNitric Oxide Synthase Type ITranslational Research, BiomedicalXenonAllopurinolBiopterinsErythropoietinMelatoninNeuroprotective AgentsNitric Oxide Synthase Type IsapropterinXenon

Identifiers

PMID22325255
PMCPMC4048707
OpenAlexW2149763277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.