Evidence map›Paper›PMID 22325189›Full record

ArticleLancet (London, England)2012

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome.

Fadi J Charchar, Lisa Ds Bloomer, Timothy A Barnes, Mark J Cowley, Christopher P Nelson, Yanzhong Wang, Matthew Denniff, Radoslaw Debiec, Paraskevi Christofidou, Scott Nankervis and 16 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lancet (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 217 citations in OpenAlex.

  1. Article
  2. Review
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  8. Sex differences in disease: sex chromosome and immunity.Journal of translational medicine · 2024
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  9. Y Chromosome Loss and Implications for Oncology.Molecular cancer research : MCR · 2024
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  10. Article
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  12. Article
  13. Sex differences in preclinical models of hypertension.Journal of human hypertension · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. Sex and gender affect immune aging.Frontiers in aging · 2023
    Review
  18. Risk factors for cardiovascular diseases during medical academic training.American journal of cardiovascular disease · 2023
    Article
  19. Why loss of Y? A pan-cancer genome analysis of tumors with loss of Y chromosome.Computational and structural biotechnology journal · 2023
    Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 13 institutions in 4 countries.

Fadi J CharcharSchool of Health Sciences, University of Ballarat, Ballarat, VIC, Australia.
Lisa Ds BloomerDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Timothy A BarnesDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Mark J CowleyPeter Wills Bioinformatics Centre, Garvan Institute for Medical Research, Sydney, NSW, Australia.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK; National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.
Yanzhong WangDivision of Health and Social Care Research, King's College London, London, UK.
Matthew DenniffDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Radoslaw DebiecDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Paraskevi ChristofidouDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Scott NankervisSchool of Health Sciences, University of Ballarat, Ballarat, VIC, Australia.
Anna F DominiczakInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Ahmed Bani-MustafaSchool of Health Sciences, University of Ballarat, Ballarat, VIC, Australia.
Anthony J BalmforthDivision of Epidemiology, LIGHT, School of Medicine, University of Leeds, Leeds, UK.
Alistair S HallDivision of Epidemiology, LIGHT, School of Medicine, University of Leeds, Leeds, UK.
Jeanette ErdmannUniversität zu Lübeck, Medizinische Klinik II, Lübeck, Germany.
Francois CambienINSERM UMRS 937, Pierre and Marie Curie University and Medical School, Paris, France.
Panos DeloukasWellcome Trust Sanger Institute, Cambridge, UK.
Christian HengstenbergKlinik und Poliklinik für Innere Medizin II, Universität Regensburg, Regensburg, Germany.
Chris PackardCollege of Medicine, Veterinary and Life Sciences, and Department of Vascular Biochemistry, University of Glasgow, Glasgow, UK.
Heribert SchunkertUniversität zu Lübeck, Medizinische Klinik II, Lübeck, Germany.
Willem H OuwehandWellcome Trust Sanger Institute, Cambridge, UK; Department of Haematology, University of Cambridge and National Health Service Blood and Transplant, Cambridge, UK.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Alison H GoodallDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK; National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.
Mark A JoblingDepartment of Genetics, University of Leicester, Leicester, UK.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK; National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.
Maciej TomaszewskiDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK; National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK. Electronic address: mt142@le.ac.uk.
University of Leicester · GBFederation University · AUUniversity of Glasgow · GBGlenfield Hospital · GBUniversity of Leeds · GBUniversity of Lübeck · DEGarvan Institute of Medical Research · AUKing's College London · GBNational Health Service · GBNational Institute for Health Research · GBSorbonne Université · FRUniversity Hospital Regensburg · DEWellcome Sanger Institute · GB

Funding

British Heart Foundation PG/06/097/21331British Heart Foundation PG/12/9/29376Wellcome TrustWellcome Trust 087576Wellcome Trust WT-0841383/2/07/2
6 · The paper itself

Abstract

backgroundA sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity.

methodsWe genotyped 11 markers of the male-specific region of the Y chromosome in 3233 biologically unrelated British men from three cohorts: the British Heart Foundation Family Heart Study (BHF-FHS), West of Scotland Coronary Prevention Study (WOSCOPS), and Cardiogenics Study. On the basis of this information, each Y chromosome was tracked back into one of 13 ancient lineages defined as haplogroups. We then examined associations between common Y chromosome haplogroups and the risk of coronary artery disease in cross-sectional BHF-FHS and prospective WOSCOPS. Finally, we undertook functional analysis of Y chromosome effects on monocyte and macrophage transcriptome in British men from the Cardiogenics Study.

findingsOf nine haplogroups identified, two (R1b1b2 and I) accounted for roughly 90% of the Y chromosome variants among British men. Carriers of haplogroup I had about a 50% higher age-adjusted risk of coronary artery disease than did men with other Y chromosome lineages in BHF-FHS (odds ratio 1·75, 95% CI 1·20-2·54, p=0·004), WOSCOPS (1·45, 1·08-1·95, p=0·012), and joint analysis of both populations (1·56, 1·24-1·97, p=0·0002). The association between haplogroup I and increased risk of coronary artery disease was independent of traditional cardiovascular and socioeconomic risk factors. Analysis of macrophage transcriptome in the Cardiogenics Study revealed that 19 molecular pathways showing strong differential expression between men with haplogroup I and other lineages of the Y chromosome were interconnected by common genes related to inflammation and immunity, and that some of them have a strong relevance to atherosclerosis.

interpretationThe human Y chromosome is associated with risk of coronary artery disease in men of European ancestry, possibly through interactions of immunity and inflammation.

fundingBritish Heart Foundation; UK National Institute for Health Research; LEW Carty Charitable Fund; National Health and Medical Research Council of Australia; European Union 6th Framework Programme; Wellcome Trust.

Indexed as

HaplotypesCase-Control StudiesChromosomes, Human, YCoronary Artery DiseaseFemaleGenotypeHumansMacrophagesMaleMiddle AgedMonocytesPolymorphism, Single NucleotideRisk FactorsSex DistributionTranscriptome

Identifiers

PMID22325189
PMCPMC3314981
OpenAlexW2149892026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.