SynthesisAmerican journal of human genetics2012
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
Synthesis in American journal of human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 160 papers, 16 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
160 citing papers in PubMed, 16 syntheses or guidelines pooled it, 267 citations in OpenAlex.
- What genes are differentially expressed in individuals with schizophrenia? A systematic review.Molecular psychiatry · 2022Pooled it
- Genetic determinants of circulating GIP and GLP-1 concentrations.JCI insight · 2017Pooled it
- Efficacy and safety of liraglutide, a once-daily human glucagon-like peptide-1 receptor agonist, in African-American people with Type 2 diabetes: a meta-analysis of sub-population data from seven phase III trials.Diabetic medicine : a journal of the British Diabetic Association · 2017Pooled it
- Pooled it
- Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.Human molecular genetics · 2016Pooled it
- A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.Pharmacogenomics · 2016Pooled it
- Common variants in DRD2 are associated with sleep duration: the CARe consortium.Human molecular genetics · 2016Pooled it
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.American journal of human genetics · 2014Pooled it
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.Nature genetics · 2014Pooled it
- Predicting risk of type 2 diabetes mellitus with genetic risk models on the basis of established genome-wide association markers: a systematic review.American journal of epidemiology · 2013Pooled it
- Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.Diabetes · 2013Pooled it
- Association between variants of EXT2 and type 2 diabetes: a replication and meta-analysis.Human genetics · 2013Pooled it
- Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.Human molecular genetics · 2013Pooled it
- Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.American journal of human genetics · 2012Pooled it
- Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.PloS one · 2012Pooled it
- Can genetic pleiotropy replicate common clinical constellations of cardiovascular disease and risk?PloS one · 2012Pooled it
- Whole-genome re-sequencing for the identification of high contribution susceptibility gene variants in patients with type 2 diabetes.Molecular medicine reports · 2016Trial
- Association Between KCNQ1 Genetic Variants and Type 2 Diabetes in the Uyghur Population.Genetic testing and molecular biomarkers · 2015Trial
- SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation.Lipids in health and disease · 2014Trial
- Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children.BMC medical genetics · 2012Trial
100 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedSever, Peter [added]; Poulter, Neil [added] Bhatt, Deepak [corrected to Bhatt, Deepak L]; Asselbergs, Folkert [corrected to Asselbergs, Folkert W]
Authors and funding
159 authors at 20 institutions in 11 countries.
Funding
Abstract
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000 candidate genes in 39 multiethnic population-based studies, case-control studies, and clinical trials totaling 17,418 cases and 70,298 controls. First, meta-analysis of 25 studies comprising 14,073 cases and 57,489 controls of European descent confirmed eight established T2D loci at genome-wide significance. In silico follow-up analysis of putative association signals found in independent genome-wide association studies (including 8,130 cases and 38,987 controls) performed by the DIAGRAM consortium identified a T2D locus at genome-wide significance (GATAD2A/CILP2/PBX4; p = 5.7 × 10(-9)) and two loci exceeding study-wide significance (SREBF1, and TH/INS; p < 2.4 × 10(-6)). Second, meta-analyses of 1,986 cases and 7,695 controls from eight African-American studies identified study-wide-significant (p = 2.4 × 10(-7)) variants in HMGA2 and replicated variants in TCF7L2 (p = 5.1 × 10(-15)). Third, conditional analysis revealed multiple known and novel independent signals within five T2D-associated genes in samples of European ancestry and within HMGA2 in African-American samples. Fourth, a multiethnic meta-analysis of all 39 studies identified T2D-associated variants in BCL2 (p = 2.1 × 10(-8)). Finally, a composite genetic score of SNPs from new and established T2D signals was significantly associated with increased risk of diabetes in African-American, Hispanic, and Asian populations. In summary, large-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and variants that contribute to T2D risk and suggests substantial overlap of T2D association signals across multiple ethnic groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.