Evidence map›Paper›PMID 22324992›Full record

ReviewFuture microbiology2012

Future perspective on host-pathogen interactions during bacterial biofilm formation within the nasopharynx.

Krystle A Blanchette, Carlos J Orihuela

Abstract readReview
In one paragraph

Review in Future microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Immunometabolism in biofilm infection: lessons from cancer.Molecular medicine (Cambridge, Mass.) · 2022
    Review
  5. Interrogation ofSaudi journal of biological sciences · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Adenoid bacterial colonization in a paediatric population.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Observational
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Krystle A BlanchetteThe University of Texas Health Science Center at San Antonio, Department of Microbiology & Immunology, 7703 Floyd Curl Drive, MC7758, San Antonio, TX 78229-3900, USA.
Carlos J Orihuela
Bipar · FRThe University of Texas Health Science Center at San Antonio · US

Funding

Mechanism of PsrP mediated adhesionR01AI078972 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ORIHUELA, CARLOS J · 2009 to 2013
$1.3M
NIAID NIH HHS AI078972NIAID NIH HHS R01 AI078972
6 · The paper itself

Abstract

Nasopharyngeal colonization provides bacteria with a place of residence, a platform for person-to-person transmission and for many opportunistic pathogens it is a prerequisite event towards the development of invasive disease. Therefore, how host factors within the nasopharynx contribute to, inhibit or otherwise shape biofilm formation, the primary mode of existence for colonizing bacteria, and how biofilm bacteria subvert the acute inflammatory response that facilitates clearance, are important topics for future microbiological research. This review proposes the examination of host components as bridging molecules for bacterial interactions during biofilm formation, altered virulence determinant production and cell wall modification as a mechanism for immunoquiescence, and the role of host factors as signals and co-opted mechanisms for bacterial dissemination, together providing an opportunity for disease.

Indexed as

BiofilmsHost-Pathogen InteractionsAdhesins, BacterialBacteriaBacterial InfectionsBacteriophagesCellular MicroenvironmentCell WallDNA, BacterialExtracellular MatrixHumansInflammationN-Acetylmuramoyl-L-alanine AmidaseNasopharynxSignal TransductionVirulence FactorsAdhesins, BacterialDNA, BacterialN-Acetylmuramoyl-L-alanine AmidaseVirulence Factors

Identifiers

PMID22324992
PMCPMC3286033
OpenAlexW2169300531

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.