ArticleThe journal of physical chemistry. B2012
Conformational distributions and hydrogen bonding in gel and frozen lipid bilayers: a high frequency spin-label ESR study.
Article in The journal of physical chemistry. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Probing the Hydrophobic Region of a Lipid Bilayer at Specific Depths Using Vibrational Spectroscopy.Journal of the American Chemical Society · 2023Article
- Time-Frequency Analysis of Two-Dimensional Electron Spin Resonance Signals.The journal of physical chemistry. A · 2023Article
- Theory and Least Squares Fitting of CW ESR Saturation Spectra Using the MOMD Model.Applied magnetic resonance · 2022Article
- Studies of transmembrane peptides by pulse dipolar spectroscopy with semi-rigid TOPP spin labels.European biophysics journal : EBJ · 2021Review
- Microsecond Exchange Processes Studied by Two-Dimensional ESR at 95 GHz.Journal of the American Chemical Society · 2020Article
- Microsecond dynamics in proteins by two-dimensional ESR: Predictions.The Journal of chemical physics · 2020Article
- Pulse EPR Measurements of Intramolecular Distances in a TOPP-Labeled Transmembrane Peptide in Lipids.Biophysical journal · 2016Article
- Interaction of Spin-Labeled Lipid Membranes with Transition Metal Ions.The journal of physical chemistry. B · 2015Article
- Cholesterol enhances surface water diffusion of phospholipid bilayers.The Journal of chemical physics · 2014Article
- Using spin-label W-band EPR to study membrane fluidity profiles in samples of small volume.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The ESR parameters of PC spin labels in frozen membranes do not simply represent the membrane polarity or water penetration profile. Instead, they show a distribution between hydrogen-bonded (HB) and non-hydrogen-bonded (non-HB) states, which is affected by a number of factors in the membrane composition. Similar to the exclusion of solutes from crystallizing solvents, the pure bulk gel phase excludes nitroxides, forcing acyl chains to take bent conformations. In these conformations, the nitroxide is hydrogen-bonded. Furthermore, upon gradual cooling in the supercooled gel, PC labels undergo slow lateral aggregation, resulting in a broad background signal. However, if the sample is instantly frozen, this background is replaced by the HB component. In membranes with cholesterol, the observed HB/non-HB ratio can best be described by a partition-like equilibrium between nitroxides located in defects of lipid structure within the hydrophobic core and those close to the membrane surface.
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Registered trials
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