ArticleOrganic process research & development2012
Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres.
Article in Organic process research & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed.
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- A Polarity-Mismatched Photocatalytic Cross-Coupling Enables Diversity-Oriented Synthesis of aza-Heterocycles.Organic letters · 2026Article
- Development and evaluation of mitochondria-targeted caseinolytic protease (ClpP) agonist chemical probes in in vitro breast cancer models.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Article
- Cu-Catalyzed Three-Component Carbofunctionalization of 1,3-Dienes.ACS catalysis · 2025Article
- Copper-catalyzed enantioselective three-component radical 1,4-perfluoroalkylamination of 1,3-dienes.Nature communications · 2025Article
- Biomimetic Dehydrogenative Intermolecular Formal Allylic Amidation of Branched α-Olefins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Enantioselective synthesis of chiral amides by carbene insertion into amide N-H bond.Nature communications · 2024Article
- Practical synthesis of allylic aminesChemical science · 2023Article
- Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions.Molecules (Basel, Switzerland) · 2023Article
- Synthesis of Veliparib Prodrugs and Determination of Drug-Release-Dependent PARP-1 Inhibition.ACS medicinal chemistry letters · 2023Article
- Mechanistic dichotomy in the solvent dependent access toChemical science · 2022Article
- EnzymaticACS sustainable chemistry & engineering · 2022Article
- Ligand-Free Copper-Catalyzed Ullmann-Type C-O Bond Formation in Non-Innocent Deep Eutectic Solvents under Aerobic Conditions.ChemSusChem · 2022Article
- Direct Synthesis of Allyl Amines with 2-Nitrosulfonamide Derivatives via the Tsuji-Trost Reaction.ChemistryOpen · 2021Article
- A Diastereodivergent and Enantioselective Approach toJournal of the American Chemical Society · 2021Article
- Ni-catalyzed hydroaminoalkylation of alkynes with amines.Nature communications · 2021Article
- PQQ-dependent Dehydrogenase Enables One-pot Bi-enzymatic Enantio-convergent Biocatalytic Amination of RacemicChemCatChem · 2021Article
- Copper-Catalyzed Decarboxylative Functionalization of ConjugatedACS catalysis · 2020Article
- Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition ofMolecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Nucleophilic imine additions with vinyl organometallics have developed into efficient, high yielding, and robust methodologies to generate structurally diverse allylic amines. We have used the hydrozirconation-transmetalation-imine addition protocol in the synthesis of allylic amine intermediates for peptide bond isosteres, phosphatase inhibitors, and mitochondria-targeted peptide mimetics. The gramicidin S-derived XJB-5-131 and JP4-039 and their analogs have been prepared on up to 160 g scale for preclinical studies. These (E)-alkene peptide isosteres adopt type II' β-turn secondary structures and display impressive biological properties, including selective reactions with reactive oxygen species (ROS) and prevention of apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.