ArticleJournal of Korean medical science2012
Relationship between Helicobacter pylori virulence genes and clinical outcomes in Saudi patients.
Article in Journal of Korean medical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Association between Helicobacter pylori infection and the types of tumor markers among Yemeni gastric cancer patients: a case-control study.BMC research notes · 2025Article
- Epidemiology, pathogenicity, risk factors, and management ofBiomolecules & biomedicine · 2024Review
- Study of vacuolating cytotoxin A (vacA) genotypes of ulcerogenic and non-ulcerogenic strains ofSaudi journal of biological sciences · 2023Article
- Molecular characterization ofSaudi medical journal · 2022Article
- Genotyping ofInternational journal of microbiology · 2021Article
- Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes.BMC gastroenterology · 2019Article
- Analysis ofGastroenterology research · 2018Article
- Prevalence ofInternational journal of microbiology · 2018Article
- TLR4 and TLR2 expression in biopsy specimens from antral and corporal stomach zones in Helicobacter pylori infections.Reports of biochemistry & molecular biology · 2014Article
- Epidemiology and pattern of antibiotic resistance in Helicobacter pylori: scenario from Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationReview
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori has been strongly associated with gastritis, gastric and duodenal ulcers, and it is a risk factor for gastric cancer. Two major virulence factors of H. pylori have been described: the cytotoxin-associated gene product (cagA) and the vacuolating toxin (vacA). Since considerable geographic diversity in the prevalence of H. pylori virulence factors has been reported, the aim of this work was to determine if there is a significant correlation between different H. pylori virulence genes (cagA and vacA) in 68 patients, from Saudi Arabia, and gastric clinical outcomes. H. pylor was recognized in cultures of gastric biopsies. vacA and cagA genes were detected by polymerase chain reaction (PCR). The cagA gene was obtained with 42 isolates (61.8%). The vacA s- and m- region genotypes were determined in all strains studied. Three genotypes were found: s1/m1 (28%), s1/m2 (40%) and s2/m2 (26%). The s2/m1 genotype was not found in this study. The relation of the presence of cagA and the development of cases to gastritis and ulcer was statistically significant (P < 0.05). The study showed a significant correlation between the vacAs1/m2 genotype and gastritis cases, and a significant correlation between vacAs1/m1 genotype and peptic ulcer cases. The results of this study might be used for the identification of high-risk patients who are infected by vacAs1/m1 genotype of H. pylori strains. In conclusion, H. pylori strains of vacA type s1 and the combination of s1/m1 were associated with peptic ulceration and the presence of cagA gene.
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