ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Arx revisited: involved in the development of GABAergic interneurons.Frontiers in cell and developmental biology · 2025Review
- Sensory Stimulation-dependent Npas4 Expression in the Olfactory Bulb during Early Postnatal Development.Experimental neurobiology · 2024Article
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.Frontiers in neural circuits · 2024Review
- A specific olfactory bulb interneuron subtype Tpbg/5T4 generated at embryonic and neonatal stages.Frontiers in neural circuits · 2024Review
- PlexinD1 signaling controls domain-specific dendritic development in newborn neurons in the postnatal olfactory bulb.Frontiers in neuroscience · 2023Article
- Trophoblast glycoprotein is a new candidate gene for Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Adiposity-related insulin resistance and thickness of the cerebral cortex in middle-aged adults.Journal of neuroendocrinology · 2020Article
- Expression and distribution of trophoblast glycoprotein in the mouse retina.The Journal of comparative neurology · 2020Article
- Distinct Developmental Features of Olfactory Bulb Interneurons.Molecules and cells · 2020Review
- LRR-Containing Oncofetal Trophoblast Glycoprotein 5T4 Shapes Neural Circuits in Olfactory and Visual Systems.Frontiers in molecular neuroscience · 2020Review
- Age-Related Olfactory Dysfunction: Epidemiology, Pathophysiology, and Clinical Management.Frontiers in aging neuroscience · 2020Review
- Identification of PKCα-dependent phosphoproteins in mouse retina.Journal of proteomics · 2019Article
- Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae.Frontiers in cellular neuroscience · 2019Article
- POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Functional Role of Olfactory Bulb Granule Cell Subtypes Derived From Embryonic and Postnatal Neurogenesis.Frontiers in molecular neuroscience · 2018Review
- The Stem Cell Marker Lgr5 Defines a Subset of Postmitotic Neurons in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Transethnic genome-wide scan identifies novel Alzheimer's disease loci.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Sensory input has been shown to regulate development in a variety of species and in various structures, including the retina, cortex, and olfactory bulb (OB). Within the mammalian OB specifically, the development of dendrites in mitral/tufted cells is well known to be odor-evoked activity dependent. However, little is known about the developmental role of sensory input in the other major OB population of the GABAgenic interneurons, such as granule cells and periglomerular cells. Here, we identified, with DNA microarray and in situ hybridization screenings, a trophoblast glycoprotein gene, 5T4, whose expression in a specific subtype of OB interneurons is dependent on sensory input. 5T4 is a type I membrane protein, whose extracellular domain contains seven leucine-rich repeats (LRR) flanked by characteristic LRR-N-flanking and C-flanking regions, and a cytoplasmic domain. 5T4 overexpression in the newborn OB interneurons facilitated their dendritic arborization even under the sensory input-deprived condition. By contrast, both 5T4 knockdown with RNAi and 5T4 knockout with mice resulted in a significant reduction in the dendritic arborization of 5T4(+) granule cells. Further, we identified the amino acid sequence in the 5T4 cytoplasmic domain that is necessary and sufficient for the sensory input-dependent dendritic shaping of specific neuronal subtypes in the OB. Thus, these results demonstrate that 5T4 glycoprotein contributes in the regulation of activity-dependent dendritic development of interneurons and the formation of functional neural circuitry in the OB.
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