ArticleJournal of neurophysiology2012
Contribution of EAG to excitability and potassium currents in Drosophila larval motoneurons.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Activity-Dependent Global Downscaling of Evoked Neurotransmitter Release across Glutamatergic Inputs inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila.BMC developmental biology · 2018Article
- Regulation of Eag by CaJournal of neurophysiology · 2018Article
- Nonreciprocal homeostatic compensation inJournal of neurophysiology · 2017Article
- Eag1 KOxidative medicine and cellular longevity · 2017Review
- Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor.The Journal of experimental biology · 2015Article
- The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons.Journal of neurophysiology · 2014Article
- External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor.The Journal of general physiology · 2013Article
- KJournal of neurogeneticsArticle
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Diversity in the expression of K(+) channels among neurons allows a wide range of excitability, growth, and functional regulation. Ether-à-go-go (EAG), a voltage-gated K(+) channel, was first characterized in Drosophila mutants by spontaneous firing in nerve terminals and enhanced neurotransmitter release. Although diverse functions have been ascribed to this protein, its role within neurons remains poorly understood. The aim of this study was to characterize the function of EAG in situ in Drosophila larval motoneurons. Whole cell patch-clamp recordings performed from the somata revealed a decrease in I(Av) and I(Kv) K(+) currents in eag mutants and with targeted eag RNAi expression. Spontaneous spike-like events were observed in eag mutants but absent in wild-type motoneurons. Thus our results provide evidence that EAG represents a unique K(+) channel contributing to multiple K(+) currents in motoneurons helping to regulate excitability, consistent with previous observations in the Drosophila larval muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.