ArticleJournal of neurophysiology2012
Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structure.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2.Nature chemical biology · 2026Article
- Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Identification of druggable binding sites and small molecules as modulators of TMC1.Communications biology · 2025Article
- The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.Nature communications · 2024Article
- Identifying targets to prevent aminoglycoside ototoxicity.Molecular and cellular neurosciences · 2022Review
- In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanically Gated Ion Channels in Mammalian Hair Cells.Frontiers in cellular neuroscience · 2018Review
- Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Underestimated sensitivity of mammalian cochlear hair cells due to splay between stereociliary columns.Biophysical journal · 2015Article
- Unconventional mechanics of lipid membranes: a potential role for mechanotransduction of hair cell stereocilia.Biophysical journal · 2015Article
- Designer aminoglycosides prevent cochlear hair cell loss and hearing loss.The Journal of clinical investigation · 2015Article
- The how and why of identifying the hair cell mechano-electrical transduction channel.Pflugers Archiv : European journal of physiology · 2015Review
- Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells.Frontiers in cellular neuroscience · 2015Article
- The physiology of mechanoelectrical transduction channels in hearing.Physiological reviews · 2014Review
- Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.The Journal of general physiology · 2014Article
- Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Adaptation of mammalian auditory hair cell mechanotransduction is independent of calcium entry.Neuron · 2013Article
- A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides.MedChemCommArticle
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Authors and funding
5 authors.
Funding
Abstract
Mechanoelectric transducer (MET) channels, located near stereocilia tips, are opened by deflecting the hair bundle of sensory hair cells. Defects in this process result in deafness. Despite this critical function, the molecular identity of MET channels remains a mystery. Inherent channel properties, particularly those associated with permeation, provide the backbone for the molecular identification of ion channels. Here, a novel channel rectification mechanism is identified, resulting in a reduced pore size at positive potentials. The apparent difference in pore dimensions results from Ca(2+) binding within the pore, occluding permeation. Driving force for permeation at hyperpolarized potentials is increased because Ca(2+) can more easily be removed from binding within the pore due to the presence of an electronegative external vestibule that dehydrates and concentrates permeating ions. Alterations in Ca(2+) binding may underlie tonotopic and Ca(2+)-dependent variations in channel conductance. This Ca(2+)-dependent rectification provides targets for identifying the molecular components of the MET channel.
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