ArticleProceedings of the National Academy of Sciences of the United States of America2012
Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- Bile acid receptors and renal regulation of water homeostasis.Frontiers in physiology · 2023Review
- Liver X Receptor Regulation of Glial Cell Functions in the CNS.Biomedicines · 2022Review
- Liver X receptorAmerican journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Significant association ofJournal of diabetes and metabolic disorders · 2021Article
- Retinal and optic nerve degeneration in liver X receptor β knockout mice.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs.International journal of molecular sciences · 2018Review
- Crosstalk of Hyperglycemia and Dyslipidemia in Diabetic Kidney Disease.Kidney diseases (Basel, Switzerland) · 2017Review
- Activation of liver X receptor inhibits OCT2-mediated organic cation transport in renal proximal tubular cells.Pflugers Archiv : European journal of physiology · 2017Article
- Unraveling the Physiology of (Pro)Renin Receptor in the Distal Nephron.Hypertension (Dallas, Tex. : 1979) · 2017Review
- Nuclear Receptor Regulation of Aquaporin-2 in the Kidney.International journal of molecular sciences · 2016Review
- Defective Store-Operated Calcium Entry Causes Partial Nephrogenic Diabetes Insipidus.Journal of the American Society of Nephrology : JASN · 2016Article
- LXR Regulation of Brain Cholesterol: From Development to Disease.Trends in endocrinology and metabolism: TEM · 2016Review
- Liver X receptors regulate cerebrospinal fluid production.Molecular psychiatry · 2016Article
- Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice.Disease models & mechanisms · 2016Article
- Emerging role of liver X receptors in cardiac pathophysiology and heart failure.Basic research in cardiology · 2016Review
- Estrogen receptor β and Liver X receptor β: biology and therapeutic potential in CNS diseases.Molecular psychiatry · 2015Review
- The oxysterol receptor LXRβ protects against DSS- and TNBS-induced colitis in mice.Mucosal immunology · 2014Article
- Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA.Nature structural & molecular biology · 2014Article
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study demonstrates a key role for the oxysterol receptor liver X receptor β (LXRβ) in the etiology of diabetes insipidus (DI). Given free access to water, LXRβ(-/-) but not LXRα(-/-) mice exhibited polyuria (abnormal daily excretion of highly diluted urine) and polydipsia (increased water intake), both features of diabetes insipidus. LXRβ(-/-) mice responded to 24-h dehydration with a decreased urine volume and increased urine osmolality. To determine whether the DI was of central or nephrogenic origin, we examined the responsiveness of the kidney to arginine vasopressin (AVP). An i.p. injection of AVP to LXRβ(-/-) mice revealed a partial kidney response: There was no effect on urine volume, but there was a significant increase of urine osmolality, suggesting that DI may be caused by a defect in central production of AVP. In the brain of WT mice LXRβ was expressed in the nuclei of magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus. In LXRβ(-/-) mice the expression of AVP was markedly decreased in the magnocellular neurons as well as in urine collected over a 24-h period. The persistent high urine volume after AVP administration was traced to a reduction in aquaporin-1 expression in the kidney of LXRβ(-/-) mice. The LXR agonist (GW3965) in WT mice elicited an increase in urine osmolality, suggesting that LXRβ is a key receptor in controlling water balance with targets in both the brain and kidney, and it could be a therapeutic target in disorders of water balance.
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