ArticleAmerican journal of respiratory cell and molecular biology2012
Maintenance and repair of the lung endothelium does not involve contributions from marrow-derived endothelial precursor cells.
Article in American journal of respiratory cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Clonal Expansion in Cardiovascular Pathology.JACC. Basic to translational science · 2024Review
- Serial intravital imaging captures dynamic and functional endothelial remodeling with single-cell resolution.JCI insight · 2021Article
- Endothelial Hypoxia-Inducible Factor-1α Is Required for Vascular Repair and Resolution of Inflammatory Lung Injury through Forkhead Box Protein M1.The American journal of pathology · 2019Article
- Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs.Journal of cell communication and signaling · 2019Article
- Sox17 is required for endothelial regeneration following inflammation-induced vascular injury.Nature communications · 2019Article
- Angiogenesis in the lung.The Journal of physiology · 2019Review
- Stem Cells in Lung Injury and Repair.The American journal of pathology · 2016Review
- Resident Endothelial Cells and Endothelial Progenitor Cells Restore Endothelial Barrier Function After Inflammatory Lung Injury.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Impaired pulmonary vascular development in bronchopulmonary dysplasia.Neonatology · 2015Review
- New vessel formation in the context of cardiomyocyte regeneration--the role and importance of an adequate perfusing vasculature.Stem cell research · 2014Review
- Lung regeneration: mechanisms, applications and emerging stem cell populations.Nature medicine · 2014Review
- Endothelial FoxM1 mediates bone marrow progenitor cell-induced vascular repair and resolution of inflammation following inflammatory lung injury.Stem cells (Dayton, Ohio) · 2014Article
- Article
- Bone marrow-derived vascular modulatory cells in pulmonary arterial hypertension.Pulmonary circulation · 2013Review
- Discrimination between lung homeostatic and injury-induced epithelial progenitor subsets by cell-density properties.Stem cells and development · 2013Article
- Endothelial colony-forming cell conditioned media promote angiogenesis in vitro and prevent pulmonary hypertension in experimental bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Nascent endothelium initiates Th2 polarization of asthma.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Lung endothelium is believed to be a quiescent tissue with the potential to exhibit rapid and effective repair after injury. Endothelial progenitor cells derived from the bone marrow have been proposed as one source of new endothelial cells that may directly contribute to pulmonary endothelial cell homeostasis and repair. Here we use bone marrow transplantation models, using purified hematopoietic stem cells (HSCs) or unfractionated whole marrow, to assess engraftment of cells in the endothelium of a variety of tissues. We find scant evidence for any contribution of bone marrow-derived cells to the pulmonary endothelium in the steady state or after recovery from hyperoxia-induced endothelial injury. Although a rare population of CD45-/CD31+/VECadherin+ bone marrow-derived cells, originating from HSCs, can be found in lung tissue after transplantation, these cells are not readily found in anatomic locations that define the pulmonary endothelium. Moreover, by tracking transplanted bone marrow cells obtained from donor transgenic mice containing endothelial lineage-selective reporters (Tie2-GFP), no contribution of bone marrow-derived cells to the adult lung, liver, pancreas, heart, and kidney endothelium can be detected, even after prolonged follow-up periods of 11 months or after recovery from hyperoxic pulmonary endothelial injury. Our findings argue against any significant engraftment of bone marrow-derived cells in the pulmonary vascular endothelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.