ArticleAmerican journal of respiratory and critical care medicine2012
Spurious inferences about long-term outcomes: the case of severe sepsis and geriatric conditions.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies.Critical care (London, England) · 2016Pooled it
- Trial
- The influence of hospitalization or intensive care unit admission on declines in health-related quality of life.Annals of the American Thoracic Society · 2015Trial
- Risk factors for physical impairment after acute lung injury in a national, multicenter study.American journal of respiratory and critical care medicine · 2014Trial
- Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up.American journal of respiratory and critical care medicine · 2013Trial
- One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial.BMJ (Clinical research ed.) · 2013Trial
- Mouse models for post-sepsis syndrome: a comparison of cecal slurry injection model versus two cecal ligation and puncture models.Frontiers in medicine · 2026Article
- Functional dependence following intensive care unit-treated sepsis: three-year follow-up results from the prospective Mid-German Sepsis Cohort (MSC).The Lancet regional health. Europe · 2024Article
- How are Long-Covid, Post-Sepsis-Syndrome and Post-Intensive-Care-Syndrome related? A conceptional approach based on the current research literature.Critical care (London, England) · 2024Review
- Influence of Sepsis on the Middle-Term Outcomes for Urinary Tract Infections in Elderly People.Microorganisms · 2023Article
- Long-Term Outcomes in Acute Respiratory Distress Syndrome: Epidemiology, Mechanisms, and Patient Evaluation.Critical care clinics · 2021Review
- Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.Nature communications · 2021Article
- Changes in Self-Rated Health After Sepsis in Older Adults: A Retrospective Cohort Study.Chest · 2020Article
- A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort.Critical care (London, England) · 2020Article
- Article
- Sex Disparities and Functional Outcomes after a Critical Illness.American journal of respiratory and critical care medicine · 2020Article
- Association between Adherence to Recommended Care and Outcomes for Adult Survivors of Sepsis.Annals of the American Thoracic Society · 2020Article
- Metabolic support in the critically ill: a consensus of 19.Critical care (London, England) · 2019Review
- Differential gene expression analysis reveals novel genes and pathways in pediatric septic shock patients.Scientific reports · 2019Article
- Early Post-Intensive Care Syndrome among Older Adult Sepsis Survivors Receiving Home Care.Journal of the American Geriatrics Society · 2019Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleSurvivors of critical illness suffer significant limitations and disabilities.
objectivesAscertain whether severe sepsis is associated with increased risk of so-called geriatric conditions (injurious falls, low body mass index [BMI], incontinence, vision loss, hearing loss, and chronic pain) and whether this association is measured consistently across three different study designs.
methodsPatients with severe sepsis were identified in the Health and Retirement Study, a nationally representative cohort interviewed every 2 years, 1998 to 2006, and in linked Medicare claims. Three comparators were used to assess an association of severe sepsis with geriatric conditions in survivors: the prevalence in the United States population aged 65 years and older, survivors' own pre-sepsis levels assessed before hospitalization, or survivors' own pre-sepsis trajectory. MEASUREMENTS AND MAIN
resultsSix hundred twenty-three severe sepsis hospitalizations were followed a median of 0.92 years. When compared with the 65 years and older population, surviving severe sepsis was associated with increased rates of low BMI, injurious falls, incontinence, and vision loss. Results were similar when comparing survivors to their own pre-sepsis levels. The association of low BMI and severe sepsis persisted when controlling for patients' pre-sepsis trajectories, but there was no association of severe sepsis with injurious falls, incontinence, vision loss, hearing loss, and chronic pain after such controls.
conclusionsGeriatric conditions are common after severe sepsis. However, severe sepsis is associated with increased rates of only a subset of geriatric conditions, not all. In studying outcomes after acute illness, failing to measure and control for both preillness levels and trajectories may result in erroneous conclusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.