ArticleMolecular biology of the cell2012
A negative feedback loop at the nuclear periphery regulates GAL gene expression.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes.bioRxiv : the preprint server for biology · 2024Article
- The Nuclear Pore Complex as a Transcription Regulator.Cold Spring Harbor perspectives in biology · 2022Review
- A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization.Molecular cell · 2021Article
- Impact of Chromosome Fusions on 3D Genome Organization and Gene Expression in Budding Yeast.Genetics · 2020Article
- The Role of Transcription Factors and Nuclear Pore Proteins in Controlling the Spatial Organization of the Yeast Genome.Developmental cell · 2019Article
- CRISPR-PIN: Modifying gene position in the nucleus via dCas9-mediated tethering.Synthetic and systems biotechnology · 2019Article
- Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals.Genes & development · 2018Article
- Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope.Molecular biology of the cell · 2018Article
- Quantitative imaging of chromatin decompaction in living cells.Molecular biology of the cell · 2018Article
- Daughter-cell-specific modulation of nuclear pore complexes controls cell cycle entry during asymmetric division.Nature cell biology · 2018Article
- Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunction.Brain, behavior, and immunity · 2018Article
- Epigenetic Transcriptional Memory ofGenetics · 2017Article
- Nuclear pore complexes and regulation of gene expression.Current opinion in cell biology · 2017Review
- Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex.Nucleic acids research · 2017Article
- Temporal and spatial regulation of mRNA export: Single particle RNA-imaging provides new tools and insights.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- High Throughput Analyses of Budding Yeast ARSs Reveal New DNA Elements Capable of Conferring Centromere-Independent Plasmid Propagation.G3 (Bethesda, Md.) · 2016Article
- Article
- Global reorganization of budding yeast chromosome conformation in different physiological conditions.The Journal of cell biology · 2016Article
- A negative loop within the nuclear pore complex controls global chromatin organization.Genes & development · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The genome is nonrandomly organized within the nucleus, but it remains unclear how gene position affects gene expression. Silenced genes have frequently been found associated with the nuclear periphery, and the environment at the periphery is believed to be refractory to transcriptional activation. However, in budding yeast, several highly regulated classes of genes, including the GAL7-10-1 gene cluster, are known to translocate to the nuclear periphery concurrent with their activation. To investigate the role of gene positioning on GAL gene expression, we monitored the effects of mutations that disrupt the interaction between the GAL locus and the periphery or synthetically tethered the locus to the periphery. Localization to the nuclear periphery was found to dampen initial GAL gene induction and was required for rapid repression after gene inactivation, revealing a function for the nuclear periphery in repressing endogenous GAL gene expression. Our results do not support a gene-gating model in which GAL gene interaction with the nuclear pore ensures rapid gene expression, but instead they suggest that a repressive environment at the nuclear periphery establishes a negative feedback loop that enables the GAL locus to respond rapidly to changes in environmental conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.