ArticleDatabase : the journal of biological databases and curation2012
dbPTB: a database for preterm birth.
Article in Database : the journal of biological databases and curation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- Targeted Sequencing and Meta-Analysis of Preterm Birth.PloS one · 2016Pooled it
- Pathway-based genetic analysis of preterm birth.Genomics · 2013Pooled it
- Transcriptome analysis of early pregnancy vitamin D status and spontaneous preterm birth.PloS one · 2020Trial
- Reproductomics: Exploring the Applications and Advancements of Computational Tools.Physiological research · 2024Review
- Integrative analysis of noncoding mutations identifies the druggable genome in preterm birth.Science advances · 2024Article
- A Data Mining Approach Reveals Chemicals Detected at Higher Levels in Non-Hispanic Black Women Target Preterm Birth Genes and Pathways.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Protein interaction networks define the genetic architecture of preterm birth.Scientific reports · 2022Article
- Identifying Candidate Genes for Short Gestation Length Trait in Chinese Qingping Pigs by Whole-Genome Resequencing and RNA Sequencing.Frontiers in genetics · 2022Article
- Epigenetic biomarkers and preterm birth.Environmental epigenetics · 2020Review
- Biomarker discovery for predicting spontaneous preterm birth from gene expression data by regularized logistic regression.Computational and structural biotechnology journal · 2020Article
- Transcriptomic analysis of fetal membranes reveals pathways involved in preterm birth.BMC medical genomics · 2019Article
- Genomic and molecular characterization of preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Machine learning approach to literature mining for the genetics of complex diseases.Database : the journal of biological databases and curation · 2019Article
- Enabling precision medicine in neonatology, an integrated repository for preterm birth research.Scientific data · 2018Article
- IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation.JCI insight · 2018Article
- A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth.Scientific reports · 2018Article
- Placental transcriptome co-expression analysis reveals conserved regulatory programs across gestation.BMC genomics · 2017Article
- Structural and genomic variation in preterm birth.Pediatric research · 2016Article
- The genomics of prematurity in an era of more precise clinical phenotyping: A review.Seminars in fetal & neonatal medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Genome-wide association studies (GWAS) query the entire genome in a hypothesis-free, unbiased manner. Since they have the potential for identifying novel genetic variants, they have become a very popular approach to the investigation of complex diseases. Nonetheless, since the success of the GWAS approach varies widely, the identification of genetic variants for complex diseases remains a difficult problem. We developed a novel bioinformatics approach to identify the nominal genetic variants associated with complex diseases. To test the feasibility of our approach, we developed a web-based aggregation tool to organize the genes, genetic variations and pathways involved in preterm birth. We used semantic data mining to extract all published articles related to preterm birth. All articles were reviewed by a team of curators. Genes identified from public databases and archives of expression arrays were aggregated with genes curated from the literature. Pathway analysis was used to impute genes from pathways identified in the curations. The curated articles and collected genetic information form a unique resource for investigators interested in preterm birth. The Database for Preterm Birth exemplifies an approach that is generalizable to other disorders for which there is evidence of significant genetic contributions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.