ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2013
The health-related quality of life burden of co-morbid cardiovascular disease and major depressive disorder in Australia: findings from a population-based, cross-sectional study.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Depression and comorbid chronic physical health diseases in the Australian population: A scoping review.The Australian and New Zealand journal of psychiatry · 2025Article
- The genetic association between major depressive disorder and coronary heart disease.Acta neuropsychiatrica · 2025Article
- Gender differences in the association between cardiovascular diseases and major depressive disorder among older adults in India.Dialogues in health · 2023Article
- Hypothyroidism, comorbidity and health-related quality of life: a population-based study.Endocrine connections · 2023Article
- Depression and health-related quality of life of patients with type 2 diabetes attending tertiary level hospitals in Dhaka, Bangladesh.Global health research and policy · 2023Article
- The Role of Perceived Social Support on Quality of Life in People with Cardiovascular Diseases.Ethiopian journal of health sciences · 2022Article
- Psychological distress as a risk factor for all-cause, chronic disease- and suicide-specific mortality: a prospective analysis using data from the National Health Interview Survey.Social psychiatry and psychiatric epidemiology · 2022Article
- Development and evaluation of air pollution-linked quality of life (AP-QOL) questionnaire: insight from two different cohorts.Environmental science and pollution research international · 2021Article
- Psychological distress, cardiometabolic diseases and musculoskeletal pain: A cross-sectional, population-based study of syndemic ill health in a Dutch fishing village.Journal of global health · 2021Article
- Psychometric properties of the Arabic version of the cardiac depression scale tested on Jordanian patients with cardiovascular diseases.BMC psychiatry · 2020Article
- Gender differences in health-related quality of life in people with severe mental illness.PloS one · 2020Article
- Quality of Life for 19,114 participants in the ASPREE (ASPirin in Reducing Events in the Elderly) study and their association with sociodemographic and modifiable lifestyle risk factors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Comparing Health-Related Quality of Life among Breast Cancer Patients Receiving Different Plans of Treatment, Egypt.Journal of community health · 2018Article
- Association between social support and health-related quality of life among Chinese rural elders in nursing homes: the mediating role of resilience.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Multimorbidity and health-related quality of life (HRQoL) in a nationally representative population sample: implications of count versus cluster method for defining multimorbidity on HRQoL.Health and quality of life outcomes · 2017Article
- Psychocardiology in the elderly.Wiener klinische Wochenschrift · 2016Review
- Health-related quality of life among Indigenous Australians diagnosed with cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Gender differences in the impact of mental disorders and chronic physical conditions on health-related quality of life among non-demented primary care elderly patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Baseline overall health-related quality of life predicts the 10-year incidence of cardiovascular events in a Chinese population.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Selective serotonin reuptake inhibitors and cardiovascular events: A systematic review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
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Authors and funding
6 authors.
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Abstract
purposeHealth-related quality of life (HRQOL) can be significantly impaired by the presence of chronic conditions such as cardiovascular disease (CVD) and major depressive disorder (MDD). The aim of this paper was to (1) identify differences in HRQOL between individuals with CVD, MDD, or both, compared to a healthy reference group, (2) establish whether the influence of co-morbid MDD and CVD on HRQOL is additive or synergistic and (3) determine the way in which depression severity interacts with CVD to influence overall HRQOL.
methodsPopulation-based data from the 2007 Australian National Survey of Mental Health and Well-being (NSMHWB) (n = 8841) were used to compare HRQOL of individuals with MDD and CVD, MDD but not CVD, CVD but not MDD, with a healthy reference group. HRQOL was measured using the Assessment of Quality of Life (AQOL). MDD was identified using the Composite International Diagnostic Interview (CIDI 3.0).
resultsOf all four groups, individuals with co-morbid CVD and depression reported the greatest deficits in AQOL utility scores (Coef: -0.32, 95% CI: -0.40, -0.23), after adjusting for covariates. Those with MDD only (Coef: -0.27, 95% CI: -0.30, -0.24) and CVD only (Coef: -0.08, 95% CI: -0.11, -0.05) also reported reduced AQOL utility scores. Second, the influence of MDD and CVD on HRQOL was shown to be additive, rather than synergistic. Third, a significant dose-response relationship was observed between depression severity and HRQOL. However, CVD and depression severity appeared to act independently of each other in impacting HRQOL.
conclusionsHRQOL is greatly impaired in individuals with co-morbid MDD and CVD; these conditions appear to influence HRQOL in an additive fashion. HRQOL alters with depression severity, therefore treating depression and improving HRQOL is of clinical importance.
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