Evidence map›Paper›PMID 22322920›Full record

ArticleDiabetologia2012

Potassium intake and risk of incident type 2 diabetes mellitus: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

R Chatterjee, L A Colangelo, H C Yeh, C A Anderson, M L Daviglus, K Liu, F L Brancati

Open access · bronzeAbstract read
In one paragraph

Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Diet and risk of diabetic retinopathy: a systematic review.European journal of epidemiology · 2018
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Plasma Proteomic Profile of Dietary Potassium and Incident CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  7. Review
  8. Sodium salt substitution for blood pressure in adults with diabetes.The Cochrane database of systematic reviews · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Hypokalemia in Diabetes Mellitus Setting.Medicina (Kaunas, Lithuania) · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

R ChatterjeeDuke University School of Medicine, Sutton Station Internal Medicine, 5832 Fayetteville Road, Suite 113, Durham, NC 27713, USA. ranee.chatterjee@duke.edu
L A Colangelo
H C Yeh
C A Anderson
M L Daviglus
K Liu
F L Brancati
Johns Hopkins University · USNorthwestern University · USDuke University · US

Funding

JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
Diabetes Research and Training CenterP60DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2008 to 2012
$9.1M
EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSISR01HL053560 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GROSS, MYRON D, JACOBS, DAVID R · 1995 to 2014
$9.0M
Patient Oriented Research in Type 2 DiabetesK24DK062222 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BRANCATI, FREDERICK L · 2002 to 2011
$1.7M
CORONARY ARTERY DISEASE RISK DEVELOPMENT IN YOUNG ADULTS-N01HC95095-268095095N01HC095095 · HC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAMS, DALE · 1989 to 2006
$376k
CORONARY HEART DISEASE RISK IN YOUNG ADULTSN01HC048047 · HC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 1985 to 2000
$171k
STUDY CORONARY HEART DISEASE RISK IN YOUNG ADULTSN01HC048050 · HC · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIDNEY, STEPHEN · 1985 to 2000
$102k
NHLBI NIH HHS N01 HC048047NHLBI NIH HHS N01 HC095095NHLBI NIH HHS N01-HC-48047NHLBI NIH HHS N01-HC-48050NHLBI NIH HHS N01-HC-95095NHLBI NIH HHS R01 HL053560NHLBI NIH HHS R01 HL 53560NIDDK NIH HHS K24 DK062222NIDDK NIH HHS K24DK62222NIDDK NIH HHS P30 DK079637NIDDK NIH HHS P60 DK079637
6 · The paper itself

Abstract

aims/hypothesisSerum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults.

methodsWe used data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Potassium intake was measured by (1) an average of three 24 h urinary potassium collections at the 5-year study visit, and (2) the CARDIA dietary assessment instrument at baseline. Incident type 2 diabetes cases were ascertained on the basis of use of diabetes medication and laboratory measurements. Analyses were adjusted for relevant confounders including intake of fruit and vegetables and other dietary factors.

resultsOf 1,066 participants with urinary potassium measurements, 99 (9.3%) developed diabetes over 15 years of follow-up. In multivariate models, adults in the lowest urinary potassium quintile were more than twice as likely to develop diabetes as their counterparts in the highest quintile (HR 2.45; 95% CI 1.08, 5.59). Of 4,754 participants with dietary history measurements, 373 (7.8%) developed diabetes over 20 years of follow-up. In multivariate models, African-Americans had a significantly increased risk of diabetes with lower potassium intake, which was not found in whites. CONCLUSIONS/

interpretationLow dietary potassium is associated with increased risk of incident diabetes in African-Americans. Randomised clinical trials are needed to determine if potassium supplementation, from either dietary or pharmacological sources, could reduce the risk of diabetes, particularly in higher-risk populations.

Indexed as

AdultBlack or African AmericanBlack PeopleDiabetes Mellitus, Type 2FemaleFruitHumansIncidenceLongitudinal StudiesMalePotassium, DietaryRiskVegetablesWhite PeoplePotassium, Dietary

Identifiers

PMID22322920
PMCPMC3934349
OpenAlexW1979558386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.