ArticleDiabetologia2012
Relationship between diabetes risk and admixture in postmenopausal African-American and Hispanic-American women.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Genetic ancestry in relation to the metabolic response to a US versus traditional Mexican diet: a randomized crossover feeding trial among women of Mexican descent.European journal of clinical nutrition · 2017Trial
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- Energy-Adjusted Dietary Inflammatory Index and Diabetes Risk in Postmenopausal Hispanic Women.Journal of the Academy of Nutrition and Dietetics · 2024Observational
- Dietary inflammatory index and cardiovascular disease risk in Hispanic women from the Women's Health Initiative.Nutrition journal · 2023Article
- Genetic admixture and cardiovascular disease risk in postmenopausal Hispanic women.International journal of cardiology · 2022Observational
- Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK.Diabetologia · 2022Article
- Leveraging genetic ancestry to study health disparities.American journal of physical anthropology · 2021Article
- Outdoor air pollution exposure and inter-relation of global cognitive performance and emotional distress in older women.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease.Brain : a journal of neurology · 2020Article
- The Association between Prebiotic Fiber Supplement Use and Colorectal Cancer Risk and Mortality in the Women's Health Initiative.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Article
- Parsing the Paradox: Hispanic Mortality in the US by Detailed Cause of Death.Journal of immigrant and minority health · 2019Article
- Association between Dietary Energy Density and Obesity-Associated Cancer: Results from the Women's Health Initiative.Journal of the Academy of Nutrition and Dietetics · 2018Article
- Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women.Journal of aging research · 2018Article
- Association between Dietary Energy Density and Incident Type 2 Diabetes in the Women's Health Initiative.Journal of the Academy of Nutrition and Dietetics · 2017Article
- Factors Associated With New-Onset Depression Following Ischemic Stroke: The Women's Health Initiative.Journal of the American Heart Association · 2017Observational
- Physical Activity Modifies the Association between Dietary Protein and Lean Mass of Postmenopausal Women.Journal of the Academy of Nutrition and Dietetics · 2017Article
- Vegetable protein intake is associated with lower gallbladder disease risk: Findings from the Women's Health Initiative prospective cohort.Preventive medicine · 2016Observational
- Article
- Relationship of pain and ancestry in African American women.European journal of pain (London, England) · 2015Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
aims/hypothesisType 2 diabetes is more prevalent in African-Americans (AFAs) and Hispanic-Americans (HAs) than in European-Americans. We assessed whether continental admixture was correlated with diabetes risk in these high-risk groups.
methodsWe estimated the proportion of sub-Saharan African (AFR), Amerindian (AMI) and European admixture using 92 ancestry-informative marker genotypes in 16,476 AFA and HA women from the Women's Health Initiative. Cox regression models were used to examine the association between admixture and diabetes risk, with and without accounting for socioeconomic status (SES) and adiposity measurements.
resultsAFR admixture was significantly associated with diabetes risk in AFA women when adjusting for entry age, neighbourhood SES and BMI or waist/hip ratio (WHR) (all p < 0.0001). In HA women, AMI admixture had significant associations with diabetes risk that remained significant after adjustment for SES and BMI (all p < 0.0005). In both AFAs and HAs, SES showed significant negative associations while BMI or WHR had significant positive associations with diabetes risk, with and without adjustment for genetic admixture. CONCLUSIONS/
interpretationIn AFAs, admixture, SES and BMI/WHR each independently contribute to diabetes risk after accounting for each of the other factors; in HAs, admixture, SES and BMI each independently contribute to diabetes risk after accounting for each of the other factors, whereas admixture is not significantly associated with diabetes risk after accounting for SES and WHR. The findings emphasise the importance of considering both genetic and environmental causes in the aetiology of type 2 diabetes.
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