ArticleDiabetologia2012
Hyperfiltration in type 1 diabetes: does it exist and does it matter for nephropathy?
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review of glomerular hyperfiltration assessment and definition in the medical literature.Clinical journal of the American Society of Nephrology : CJASN · 2015Pooled it
- Association of Serum Creatinine, Urea, and Glomerular Filtration Rate with the Progression of Diabetic Associated Kidney Complications: A Retrospective Case-Control Study.Current issues in molecular biology · 2026Article
- Progression and regression of kidney disease in type 1 diabetes.Frontiers in nephrology · 2023Review
- Glomerular hyperfiltration.Nature reviews. Nephrology · 2022Review
- Renal haemodynamic and protective effects of renoactive drugs in type 2 diabetes: Interaction with SGLT2 inhibitors.Nephrology (Carlton, Vic.) · 2021Review
- Estimating glomerular filtration rate in youth with obesity and type 2 diabetes: the iCARE study equation.Pediatric nephrology (Berlin, Germany) · 2019Observational
- SGLT2 inhibition in a kidney with reduced nephron number: modeling and analysis of solute transport and metabolism.American journal of physiology. Renal physiology · 2018Article
- Does significant renal ablation truly and invariably lead to hyperfiltration and progressive chronic kidney disease?Clinical and experimental nephrology · 2017Review
- Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease.Journal of diabetes investigation · 2017Review
- Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment.Journal of the American Society of Nephrology : JASN · 2017Review
- Incidence and Mortality Rates and Clinical Characteristics of Type 1 Diabetes among Children and Young Adults in Cochabamba, Bolivia.Journal of diabetes research · 2017Article
- Are SGLT2 inhibitors reasonable antihypertensive drugs and renoprotective?Current hypertension reports · 2015Review
- The effect of renal hyperfiltration on urinary inflammatory cytokines/chemokines in patients with uncomplicated type 1 diabetes mellitus.Diabetologia · 2013Article
- Diabetes: hyperfiltration-a risk factor for nephropathy in T1DM?Nature reviews. Endocrinology · 2012Article
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisHyperfiltration is widely regarded as a contributing factor to the development of microalbuminuria and progressive nephropathy in type 1 diabetes. However, recent studies have questioned this conclusion.
methodsTo address this conflicting evidence, we examined the association between hyperfiltration and progression to microalbuminuria in 2,318 adults with type 1 diabetes. We also compared the estimated GFR in our diabetic patients with rates observed in 6,247 adults from the Finnish general population, using age- and sex-specific z scores.
resultsThe distribution of estimated GFR in adults with type 1 diabetes and normoalbuminuria was not significantly different from that expected in the general population (p = 0.51, Mann-Whitney test). Type 1 diabetic patients with a higher estimated GFR were also no more likely to develop microalbuminuria over a median of 5.2 years of follow-up than those with normal estimated GFR. This was the case regardless of whether hyperfiltration was defined by an absolute threshold, deciles of estimated GFR or a z score, using creatinine- or cystatin-based clearance formulas in men or in women. CONCLUSIONS/
interpretationTogether with other studies, these data suggest that creatinine- or cystatin-based estimates of GFR do not predict the development of microalbuminuria in patients with type 1 diabetes. Moreover, in the absence of incipient or overt nephropathy, conventionally determined renal function in patients with type 1 diabetes appears no different from that in the general population. This is hardly surprising, given that these individuals, by all definitions, do not have kidney disease.
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