ArticleNeurotoxicology2012
Tremor, olfactory and motor changes in Italian adolescents exposed to historical ferro-manganese emission.
Article in Neurotoxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 4 of them syntheses that pooled it.
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Who cites it
147 citing papers in PubMed, 4 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis.Environmental health : a global access science source · 2020Pooled it
- Measuring the impact of manganese exposure on children's neurodevelopment: advances and research gaps in biomarker-based approaches.Environmental health : a global access science source · 2016Pooled it
- Neurobehavioural effects of developmental toxicity.The Lancet. Neurology · 2014Pooled it
- The neurobehavioral impact of manganese: results and challenges obtained by a meta-analysis of individual participant data.Neurotoxicology · 2013Pooled it
- Multi-matrix copper exposure is associated with reduced olfactory bulb volume and odor sensitivity in adolescents.medRxiv : the preprint server for health sciences · 2026Article
- Reframing welders' parkinsonism: from the "idiopathic" label to biological causation and legal recognition.Annals of occupational and environmental medicine · 2026Review
- Manganese: biology, physiology and role in disease.Cell discovery · 2026Review
- The Role and Mechanism of the cGAS-STING/NLRP3 Signaling Axis-Regulated p38 MAPK/NF-κB Pathway in Manganese-Induced Tau Aggregation-Mediated Neurotoxicity.Environment & health (Washington, D.C.) · 2026Article
- Fetal and postnatal metal metabolism-related changes in brain function are associated with childhood behavioral deficits.Science advances · 2026Article
- Paper-Based Microfluidics Platform for Enhanced On-Site Electrochemical Detection of Manganese in Water.ACS omega · 2026Article
- Hair biomonitoring reveals spatial heterogeneity of multielement exposure in Bogotá schoolchildren.Environmental geochemistry and health · 2026Article
- Manganese Exposure Is Associated with Reduced Grip Strength: Evidence from Humans and Mice.Toxics · 2025Article
- Impact of manganese and metal mixtures in blood, hair, and soil on child adaptive behaviors in Southeast Side Chicago.Environmental research · 2025Article
- Impact of Manganese on Neuronal Function: An Exploratory Multi-Omics Study on Ferroalloy Workers in Brescia, Italy.Brain sciences · 2025Article
- Elevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study.Translational psychiatry · 2024Article
- Do toenail manganese and iron levels reflect brain metal levels or brain metabolism in welders?Neurotoxicology · 2024Article
- Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- A multi-environmental source approach to explore associations between metals exposure and olfactory identification among school-age children residing in northern Italy.Journal of exposure science & environmental epidemiology · 2024Article
- Elevated thyroid manganese reduces thyroid iodine to induce hypothyroidism in mice, but not rats, lacking SLC30A10 transporter.Metallomics : integrated biometal science · 2024Article
87 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectiveIncreased prevalence of Parkinsonism was observed in Valcamonica, Italy, a region impacted by ferroalloy plants emissions containing manganese and other metals for a century until 2001. The aim of this study was to assess neurobehavioral functions in adolescents from the impacted region and the reference area of Garda Lake.
methodsAdolescents age 11-14 years were recruited through the school system for neuro-behavioral testing. Metals including manganese, lead, iron, zinc, copper were measured in airborne particulate matter collected with 24-h personal samplers, and in soil, tap water, blood, urine and hair. Independent variables included parental education and socio-economic status, children's body mass index, number of siblings, parity order, smoking and drinking habits.
resultsA total of 311 subjects (49.2% females), residing in either the exposed (n=154) or the reference (n=157) area participated. Average airborne and soil manganese were respectively 49.5 ng/m(3) (median 31.4, range 1.24-517) and 958 ppm (median 897, range 465-1729) in the impacted area, and 27.4 ng/m(3) (median 24.7, range 5.3-85.9) ng/m(3) and 427 ppm (median 409 range 160-734) in the reference area. Regression models showed significant impairment of motor coordination (Luria-Nebraska test, p=0.0005), hand dexterity (Aiming Pursuit test, p=0.0115) and odor identification (Sniffin' task, p=0.003) associated with soil manganese. Tremor intensity was positively associated with blood (p=0.005) and hair (p=0.01) manganese.
conclusionHistorical environmental exposure to manganese from ferroalloy emission reflected by the concentration in soil and the biomarkers was associated with sub-clinical deficits in olfactory and motor function among adolescents.
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