ReviewNeuroscience letters2012
Building stem cell niches from the molecule up through engineered peptide materials.
Review in Neuroscience letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Review
- Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel-Cell Interactions.Journal of the American Chemical Society · 2024Review
- Custom-engineered hydrogels for delivery of human iPSC-derived neurons into the injured cervical spinal cord.Biomaterials · 2024Article
- Supramolecular assembly of protein building blocks: from folding to function.Nano convergence · 2022Review
- Repairing sciatic nerve injury with self-assembling peptide nanofiber scaffold-containing chitosan conduit.Frontiers in neurology · 2022Article
- Endothelial cell secreted VEGF-C enhances NSC VEGFR3 expression and promotes NSC survival.Stem cell research · 2021Article
- Identification of Novel FNIN2 and FNIN3 Fibronectin-Derived Peptides That Promote Cell Adhesion, Proliferation and Differentiation in Primary Cells and Stem Cells.International journal of molecular sciences · 2021Article
- Designer Self-Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone.Scientific reports · 2019Article
- Engineering hydrogels with affinity-bound laminin as 3D neural stem cell culture systems.Biomaterials science · 2019Article
- A roadmap for promoting endogenous in situ tissue restoration using inductive bioscaffolds after acute brain injury.Brain research bulletin · 2019Review
- Plasmonic Nanofactors as Switchable Devices to Promote or Inhibit Neuronal Activity and Function.Nanomaterials (Basel, Switzerland) · 2019Review
- Bioscaffold-Induced Brain Tissue Regeneration.Frontiers in neuroscience · 2019Review
- Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate.Frontiers in chemistry · 2019Review
- Enhanced growth and differentiation of myoblast cells grown on E-jet 3D printed platforms.International journal of nanomedicine · 2019Article
- Construction of a Multilayered Mesenchymal Stem Cell Sheet with a 3D Dynamic Culture System.Journal of visualized experiments : JoVE · 2018Article
- Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review.Computational and structural biotechnology journal · 2018Review
- Mechano-Transduction Signals Derived from Self-Assembling Peptide Nanofibers Containing Long Motif of Laminin Influence Neurogenesis in In-Vitro and In-Vivo.Molecular neurobiology · 2017Article
- Article
- Self-Assembling Peptide Nanofiber Containing Long Motif of Laminin Induces Neural Differentiation, Tubulin Polymerization, and Neurogenesis: In Vitro, Ex Vivo, and In Vivo Studies.Molecular neurobiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The native stem cell niche is a dynamic and complex microenvironment. Recapitulating this niche is a critical focus within the fields of stem cell biology, tissue engineering, and regenerative medicine and requires the development of well-defined, tunable materials. Recent biomaterial design strategies seek to create engineered matrices that interact with cells at the molecular scale and allow on-demand, cell-triggered matrix modifications. Peptide and protein engineering can accomplish these goals through the molecular-level design of bioinductive and bioresponsive materials. This brief review focuses on engineered peptide and protein materials suitable for use as in vitro neural stem cell niche mimics and in vivo central nervous system repair. A key hallmark of these materials is the immense design freedom to specify the exact amino acid sequence leading to multi-functional bulk materials with tunable properties. These advanced materials are engineered using rational design strategies to recapitulate key aspects of the native neural stem cell niche. The resulting materials often combine the advantages of biological matrices with the engineering control of synthetic polymers. Future design strategies are expected to endow these materials with multiple layers of bi-directional feedback between the cell and the matrix, which will lead to more advanced mimics of the highly dynamic neural stem cell niche.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.