ArticleGenome biology and evolution2012
Rate of amino acid substitution is influenced by the degree and conservation of male-biased transcription over 50 myr of Drosophila evolution.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Conservation and divergence of sex-biased gene expression across 50 million years of Drosophila evolution.Molecular biology and evolution · 2026Article
- Population genomics ofbioRxiv : the preprint server for biology · 2026Article
- Evolutionary Analysis of Sex-Biased Gene Suggests Functional Conservation of Lifespan-Related Genes in Insecta.Biology · 2025Article
- Domestication affects sex-biased gene expression evolution in the duck.Royal Society open science · 2023Article
- Multi-tissue RNA-Seq Analysis and Long-read-based Genome Assembly Reveal Complex Sex-specific Gene Regulation and Molecular Evolution in the Manila Clam.Genome biology and evolution · 2022Article
- Dynamics of sex-biased gene expression during development in the stick insect Timema californicum.Heredity · 2022Article
- Transcriptome analysis of sex-biased gene expression in the spotted-wing Drosophila, Drosophila suzukii (Matsumura).G3 (Bethesda, Md.) · 2022Article
- Sex chromosome degeneration, turnover, and sex-biased expression of sex-linked transcripts in African clawed frogs (Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Review
- Absence of a Faster-X Effect in Beetles (G3 (Bethesda, Md.) · 2020Article
- Article
- Conservation, acquisition, and functional impact of sex-biased gene expression in mammals.Science (New York, N.Y.) · 2019Article
- Pleiotropy Modulates the Efficacy of Selection in Drosophila melanogaster.Molecular biology and evolution · 2019Article
- Selection shapes turnover and magnitude of sex-biased expression in Drosophila gonads.BMC evolutionary biology · 2019Article
- Support for the Dominance Theory inGenetics · 2018Article
- Comparative Transcriptomics in Two Bivalve Species Offers Different Perspectives on the Evolution of Sex-Biased Genes.Genome biology and evolution · 2018Article
- Accelerated Evolution of Developmentally Biased Genes in the Tetraphenic Ant Cardiocondyla obscurior.Molecular biology and evolution · 2017Article
- Article
- Molecular Mechanisms and Evolutionary Processes Contributing to Accelerated Divergence of Gene Expression on the Drosophila X Chromosome.Molecular biology and evolution · 2015Article
- Variation in promiscuity and sexual selection drives avian rate of Faster-Z evolution.Molecular ecology · 2015Article
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2 authors.
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Abstract
Sex-biased gene expression (i.e., the differential expression of genes between males and females) is common among sexually reproducing species. However, genes often differ in their sex-bias classification or degree of sex bias between species. There is also an unequal distribution of sex-biased genes (especially male-biased genes) between the X chromosome and the autosomes. We used whole-genome expression data and evolutionary rate estimates for two different Drosophilid lineages, melanogaster and obscura, spanning an evolutionary time scale of around 50 Myr to investigate the influence of sex-biased gene expression and chromosomal location on the rate of molecular evolution. In both lineages, the rate of protein evolution correlated positively with the male/female expression ratio. Genes with highly male-biased expression, genes expressed specifically in male reproductive tissues, and genes with conserved male-biased expression over long evolutionary time scales showed the fastest rates of evolution. An analysis of sex-biased gene evolution in both lineages revealed evidence for a "fast-X" effect in which the rate of evolution was greater for X-linked than for autosomal genes. This pattern was particularly pronounced for male-biased genes. Genes located on the obscura "neo-X" chromosome, which originated from a recent X-autosome fusion, showed rates of evolution that were intermediate between genes located on the ancestral X-chromosome and the autosomes. This suggests that the shift to X-linkage led to an increase in the rate of molecular evolution.
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