ArticleBMC research notes2012
Computational prediction of MicroRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor.
Article in BMC research notes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats.Frontiers in pharmacology · 2025Article
- Predictive and concurrent validity of pain sensitivity phenotype, neuropeptidomics and neuroepigenetics in the MI-RAT osteoarthritic surgical model in rats.Frontiers in cell and developmental biology · 2024Article
- Pathogenic variants of human GABRA1 gene associated with epilepsy: A computational approach.Heliyon · 2023Article
- Regulation of influenza A virus infection by Lnc-PINK1-2:5.Journal of cellular and molecular medicine · 2022Article
- MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway.Frontiers in molecular neuroscience · 2021Article
- MicroRNA-22 enhances the differentiation of mouse induced pluripotent stem cells into alveolar epithelial type II cells.European journal of histochemistry : EJH · 2020Article
- Regulation of GABAInternational journal of molecular sciences · 2020Review
- Long Noncoding RNA FENDRR Exhibits Antifibrotic Activity in Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2020Article
- Sex Differences in the Expression of the α5 Subunit of the GABAAlcoholism, clinical and experimental research · 2020Article
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- MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation.The Journal of biological chemistry · 2017Article
- Inhibition of miR-203 Reduces Spontaneous Recurrent Seizures in Mice.Molecular neurobiology · 2017Article
- miR-27b inhibits fibroblast activation via targeting TGFβ signaling pathway.BMC cell biology · 2017Article
- Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain.Molecular autism · 2017Article
- MicroRNA's impact on neurotransmitter and neuropeptide systems: small but mighty mediators of anxiety.Pflugers Archiv : European journal of physiology · 2016Review
- MicroRNA-26b Modulates the NF-κB Pathway in Alveolar Macrophages by Regulating PTEN.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- GABAergic mechanisms regulated by miR-33 encode state-dependent fear.Nature neuroscience · 2015Article
- GABA receptors in a state of fear.Nature neuroscience · 2015Article
- Role of MicroRNA in Visceral Pain.Journal of neurogastroenterology and motility · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGABA receptors are well known as the inhibitory receptors in the central nervous system and are also found in peripheral tissues. We have previously shown that GABA receptors are involved in lung development and fluid homeostasis. However, the microRNAs that regulate GABA receptors have not yet been identified.
resultsIn this study, we used the online software, TargetScan and miRanda, to query the microRNAs that directly target GABA receptors and then selected some of them to verify experimentally using 3'-UTR reporter assays. Computational approaches predict many microRNA binding sites on the 3'-UTR of GABAA receptors, but not on GABAC receptors. 3'-UTR reporter assays only verified miR-181, miR-216, and miR-203 as the microRNAs that target GABA receptor α1-subunit among 10 microRNAs tested.
conclusionsOur studies reinforce that microRNA target prediction needs to be verified experimentally. The identification of microRNAs that target GABA receptors provides a basis for further studies of post-transcriptional regulation of GABA receptors.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.