Evidence map›Paper›PMID 22321107›Full record

ReviewCritical reviews in immunology2011

Induction and function of IFNβ during viral and bacterial infection.

Uma Nagarajan

Open access · greenAbstract readReview
In one paragraph

Review in Critical reviews in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Immunomodulatory Role of Interferons in Viral and Bacterial Infections.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Interferon-β Activity Is Affected by S100B Protein.International journal of molecular sciences · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Uma NagarajanDivision of Pediatric Infectious Diseases, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, USA. nagarajanuma@uams.edu
Arkansas Children's Hospital · US

Funding

Molecular Mechanisms of Type I IFN Induction during Chlamydia InfectionR01AI067678 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, UMA M · 2007 to 2018
$3.5M
NIAID NIH HHS AI067678NIAID NIH HHS R01 AI067678
6 · The paper itself

Abstract

Since the discovery of the protein "interferon" over 50 years ago, IFNβ, an antiviral cytokine, has been well studied. In particular, the pathways inducing this cytokine during viral infection have been characterized, leading to the discovery of a multitude of pattern recognition receptors. IFNβ is also induced during bacterial infection, following recognition of bacterial ligands by the host viral and DNA sensors. However, the function of IFNβ during bacterial infection is variable and sometimes detrimental to the host. This review discusses the currently identified receptors and pathways engaged in IFNβ induction during infection, with emphasis on the role of IFNβ during bacterial infection.

Indexed as

AnimalsBacterial InfectionsHumansInterferon-betaReceptors, ImmunologicSignal TransductionVirus DiseasesInterferon-betaReceptors, Immunologic

Identifiers

PMID22321107
PMCPMC3281552
OpenAlexW1981740883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.