SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2012
Laparoscopic or open cholecystectomy in cirrhosis: a systematic review of outcomes and meta-analysis of randomized trials.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Should All Minimal Access Surgery Be Robot-Assisted? A Systematic Review into the Musculoskeletal and Cognitive Demands of Laparoscopic and Robot-Assisted Laparoscopic Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Pooled it
- Laparoscopic versus open liver resection: a meta-analysis of long-term outcome.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2014Pooled it
- Prevention of bile duct injury - A bird's eye view.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Review
- Impact of Opium Addiction on Liver Function and Biliary Tract in Patients with Bile Duct Stones: A Case-Control Study.Addiction & health · 2025Article
- Pre-Operative Assessment of Patients with Cirrhosis for Extrahepatic Surgery.Current hepatology reports · 2025Review
- Surgical risk stratification in patients with cirrhosis.Hepatology international · 2024Review
- Retrospective comparison of clinical outcomes of ultrasound-guided percutaneous cholecystostomy in patients with and without coagulopathy: a single center's experience.Japanese journal of radiology · 2023Article
- Management of Gallstones and Acute Cholecystitis in Patients with Liver Cirrhosis: What Should We Consider When Performing Surgery?Gut and liver · 2021Review
- Trends in surgical volume and in-hospital mortality among United States cirrhosis hospitalizations.Annals of gastroenterology · 2021Article
- Laparoscopic cholecystectomy in patients with liver cirrhosis: 8 years experience in a tertiary center. A retrospective cohort study.Annals of medicine and surgery (2012) · 2020Article
- Current status of postoperative infections after digestive surgery in Japan: The Japan Postoperative Infectious Complications Survey in 2015.Annals of gastroenterological surgery · 2019Article
- Non-Hepatic Abdominal Surgery in Patients with Cirrhotic Liver Disease.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Review
- Hepatic Pedicle Occlusion with the Pringle Maneuver During Difficult Laparoscopic Cholecystectomy Reduces the Conversion Rate.World journal of surgery · 2019Article
- Perioperative Care of Patients With Liver Cirrhosis: A Review.Health services insights · 2017Review
- Living donor liver transplantation indicated for compensated liver cirrhosis with symptomatic gallstone diseases: report of two cases.Surgical case reports · 2016Article
- Hepatobiliary Quiz Answers - 18 (2016).Journal of clinical and experimental hepatology · 2016Article
- Risk stratification and preoperative evaluation of the patient with known or suspected liver disease.Clinical liver disease · 2016Review
- Laparoscopic surgery: A qualified systematic review.World journal of methodology · 2015Article
- Laparoscopic cholecystectomy: consensus conference-based guidelines.Langenbeck's archives of surgery · 2015Review
- Gallstones in patients with liver cirrhosis: incidence, etiology, clinical and therapeutical aspects.World journal of gastroenterology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholecystectomy is associated with increased risks in patients with cirrhosis. The well-established advantages of laparoscopic surgery may be offset by the increased risk for complications relating particularly to portal hypertension and coagulopathy.
methodsA systematic search was undertaken to identify studies comparing open cholecystectomy (OC) and laparoscopic cholecystectomy (LC) in patients with cirrhosis. A meta-analysis was performed of the available randomized controlled trials (RCTs).
resultsForty-four studies were analysed. These included a total of 2005 patients with cirrhosis who underwent laparoscopic (n= 1756) or open (n= 249) cholecystectomy, with mortality rates of 0.74% and 2.00%, respectively. A meta-analysis of three RCTs involving a total of 220 patients was conducted. There was a reduction in the overall incidences of postoperative complications and infectious complications and a shorter length of hospital stay in LC. However, frequencies of postoperative hepatic insufficiency did not differ significantly.
conclusionsThere are few RCTs comparing OC and LC in patients with cirrhosis. These studies are small, heterogeneous in design and include almost exclusively patients with Child-Pugh class A and B disease. However, LC appears to be associated with shorter operative time, reduced complication rates and reduced length of hospital stay.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.