ArticleCancer science2012
Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia.
Article in Cancer science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Role of Dicer as a prognostic predictor for survival in cancer patients: a systematic review with a meta-analysis.Oncotarget · 2016Pooled it
- Possible role of human ribonuclease dicer in the regulation of R loops.FEBS open bio · 2025Review
- Review
- Dicer Enhances Bevacizumab-Related Inhibition of Hepatocellular Carcinoma via Blocking the Vascular Endothelial Growth Factor Pathway.Journal of hepatocellular carcinoma · 2021Article
- A computational approach to the study of interactions between proteins and miR10-b, miR-335, and miR-21 involved in breast cancer.Contemporary oncology (Poznan, Poland) · 2019Article
- MicroRNAs in Autoimmunity and Hematological Malignancies.International journal of molecular sciences · 2018Review
- Prostate cancer small non-coding RNA transcriptome in Arabs.Journal of translational medicine · 2017Article
- Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis.Journal of hematology & oncology · 2017Review
- Applications of Extracellular RNAs in Oncology.Molecular diagnosis & therapy · 2017Review
- Article
- Prognostic significance of Dicer expression in hepatocellular carcinoma.Oncology letters · 2016Article
- Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers.International journal of molecular sciences · 2016Review
- Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province.Iranian journal of medical sciences · 2016Article
- Combined clinical and genomic signatures for the prognosis of early stage non-small cell lung cancer based on gene copy number alterations.BMC genomics · 2015Article
- Low DICER1 expression is associated with attenuated neutrophil differentiation and autophagy of NB4 APL cells.Journal of leukocyte biology · 2015Article
- MicroRNA Processing and Human Cancer.Journal of clinical medicine · 2015Review
- MicroRNA biogenesis pathways in cancer.Nature reviews. Cancer · 2015Review
- Article
- MicroRNA Machinery Genes as Novel Biomarkers for Cancer.Frontiers in oncology · 2014Review
- Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival.BMC clinical pathology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Alterations in microRNAs (miRNAs) expression have been proposed to play a role in CLL pathogenesis. Dicer and Drosha are the main regulators of miRNA biogenesis, and deregulation of their expression has been indicated as a possible cause of miRNA alterations observed in various cancers. To investigate the role of Dicer and Drosha in CLL, we assessed the expression of Dicer and Drosha and their correlation with other prognostic factors, including Binet stages, immunoglobulin heavy chain variable gene (IGHV) mutation status, TP53 mutation status, ZAP-70 protein and CD38 expression level in 165 CLL patients by using real-time polymerase chain reaction methods. Patients with unmutated IGHV genes had significantly lower expression of Dicer than patients with IGHV mutations. The lower expression level of Dicer was also significantly associated with higher level of CD38 and ZAP-70, and more aggressive Binet stage. We also analyzed Dicer expression in different cytogenetic subgroups. Lower Dicer level was found in patients with unfavorable cytogenetic aberrations (deletion in 17p13 or 11q22.3) in contrast to higher level in good risk cytogenetics (deletion in 13q14 as the sole abnormality). Furthermore, the lower expression of Dicer in CLL shows a strong association with shorter overall survival (OS) (P = 0.0046) as well as with reduced treatment free survival (TFS) (P = 0.0006). By contrast, no differences in the expression of Drosha among these groups of patients were observed. Our data suggest that Dicer expression may play an important role in the progression and prognosis of CLL.
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Registered trials
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