ArticleSpermatogenesis2011
Estrogens in male germ cells.
Article in Spermatogenesis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Clinical Electrophysiology and Mathematical Modeling for Precision Diagnosis of Infertility.Biomedicines · 2025Review
- Hormonal Function of Undescended Testes Before Orchidopexy in Prepubertal Boys.Journal of clinical medicine · 2024Article
- Article
- Letrozole administration effects on the P450aromatase expression and the reproductive parameters in male sheep (Animal reproduction · 2023Article
- The Aromatase-Estrogen System in the Testes of Non-Mammalian Vertebrates.Animals : an open access journal from MDPI · 2021Review
- Sex Hormones and Lung Inflammation.Advances in experimental medicine and biology · 2021Article
- Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus.European journal of histochemistry : EJH · 2020Article
- Initiation of sex change and gonadal gene expression in black sea bass (Centropristis striata) exposed to exemestane, an aromatase inhibitor.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2019Article
- Orexin A-Mediated Modulation of Reproductive Activities in Testis of Normal and Cryptorchid Dogs: Possible Model for Studying Relationships Between Energy Metabolism and Reproductive Control.Frontiers in endocrinology · 2019Article
- Effects of a soybean milk product on feto-neonatal development in rats.Journal of biomedical research · 2017Article
- Effect Of Microgravity On Aromatase Expression In Sertoli Cells.Scientific reports · 2017Article
- Aberrant Wnt/β-Catenin Signaling Pathway in Testis of Azoospermic Men.Advanced pharmaceutical bulletin · 2015Article
- Expression of genomic functional estrogen receptor 1 in mouse sertoli cells.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Intra-testicular signals regulate germ cell progression and production of qualitatively mature spermatozoa in vertebrates.Frontiers in endocrinology · 2014Review
- Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals.Expert opinion on therapeutic targets · 2013Review
- Estrogens and spermiogenesis: new insights from type 1 cannabinoid receptor knockout mice.International journal of endocrinology · 2013Review
- Physiopathological aspects of the Wnt/β-catenin signaling pathway in the male reproductive system.Spermatogenesis · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biosynthesis of steroids and the production of spermatozoa are two major functions of the mammalian testis which are tightly controlled by gonadotropins and numerous locally produced factors. Among these are the estrogens that are produced within the seminiferous epithelium via the irreversible transformation of androgens (C19) into estrogens (C18) by aromatase. We have recently reported that male germ cells are the new source of estrogens in the testis. For instance, estrogen receptors (ER) are found mainly in spermatids that give rise to spermatozoa. Moreover, it is noteworthy that GPR 30 (a transmembrane ER) induces rapid responses after estradiol binding, which, in turn, modulates cyclins and proapoptotic factors (e.g., BAX) to affect germ cell cycle progression and apoptosis. In summary, at least in the animal species that were studied thus far, germ cells are the major source and the target of estrogens, affecting normal male gonadal development and spermatogenesis, in particular spermiogenesis. These findings have also shed new light on the possible adverse effects of endocrine disruptors having estrogenic activities that can cause abnormal development of the male genital tract.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.