ArticlePloS one2012
Serum from calorie-restricted rats activates vascular cell eNOS through enhanced insulin signaling mediated by adiponectin.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions.The journal of cardiovascular aging · 2025Article
- Adiponectin reverses β-Cell damage and impaired insulin secretion induced by obesity.Aging cell · 2023Article
- Article
- The role of perivascular adipose tissue in obesity-induced vascular dysfunction.British journal of pharmacology · 2017Review
- Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity.Aging cell · 2017Article
- Redox Mechanisms Influencing cGMP Signaling in Pulmonary Vascular Physiology and Pathophysiology.Advances in experimental medicine and biology · 2017Article
- Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects.British journal of pharmacology · 2014Article
- Effects of interventions on adiponectin and adiponectin receptors.Journal of exercise rehabilitation · 2014Review
- Adrenoreceptors and nitric oxide in the cardiovascular system.Frontiers in physiology · 2013Review
- Calorie restriction hysteretically primes aging Saccharomyces cerevisiae toward more effective oxidative metabolism.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
eNOS activation resulting in mitochondrial biogenesis is believed to play a central role in life span extension promoted by calorie restriction (CR). We investigated the mechanism of this activation by treating vascular cells with serum from CR rats and found increased Akt and eNOS phosphorylation, in addition to enhanced nitrite release. Inhibiting Akt phosphorylation or immunoprecipitating adiponectin (found in high quantities in CR serum) completely prevented the increment in nitrite release and eNOS activation. Overall, we demonstrate that adiponectin in the serum from CR animals increases NO• signaling by activating the insulin pathway. These results suggest this hormone may be a determinant regulator of the beneficial effects of CR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.