ArticlePloS one2012
CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment.Nature communications · 2023Article
- Decreased Astrocytic CCL2 Accounts for BAF-312 Effect on PBMCs Transendothelial Migration Through a Blood Brain Barrier in Vitro Model.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022Article
- Sex steroid hormone function in the brain niche: Implications for brain metastatic colonization and progression.Cancer reports (Hoboken, N.J.) · 2022Review
- The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain.Science advances · 2021Article
- Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury.Journal of neuroinflammation · 2020Article
- Integrated Analysis to Evaluate the Prognostic Value of Signature mRNAs in Glioblastoma Multiforme.Frontiers in genetics · 2020Article
- Imbalance of immunological synapse-kinapse states reflects tumor escape to immunity in glioblastoma.JCI insight · 2018Article
- Voltage Gated Potassium Channel Kv1.3 Is Upregulated on Activated Astrocytes in Experimental Autoimmune Encephalomyelitis.Neurochemical research · 2018Article
- Downregulation of CCL2 induced by the upregulation of microRNA-206 is associated with the severity of HEV71 encephalitis.Molecular medicine reports · 2017Article
- Tyrosine receptor kinase B is a drug target in astrocytomas.Neuro-oncology · 2017Article
- Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation.EMBO reports · 2016Article
- Microarray data analysis to identify crucial genes regulated by CEBPB in human SNB19 glioma cells.World journal of surgical oncology · 2016Article
- CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells.Cancer research · 2016Article
- Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.Biochimica et biophysica acta · 2016Article
- Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.Oncotarget · 2016Article
- Interaction of astrocytes and T cells in physiological and pathological conditions.Brain research · 2015Review
- Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis.Journal of neuroimmunology · 2014Article
- A role for human brain pericytes in neuroinflammation.Journal of neuroinflammation · 2014Article
- Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation.Journal of neuroinflammation · 2014Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the brain and in three different species. We observe that CCL2+ astrocytes play a part in the infiltration of T-cells in the brain and our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important event for lymphocyte extravasation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.