Evidence map›Paper›PMID 22319551›Full record

ReviewCurrent opinion in virology2011

Animal virus schemes for translation dominance.

Lucas C Reineke, Richard E Lloyd

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Production of YP170 Vitellogenins Promotes Intestinal Senescence in Caenorhabditis elegans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lucas C ReinekeDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Richard E Lloyd

Funding

Translation Regulation by Enterovirus ProteinaseR01AI050237 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI LLOYD, RICHARD E · 2002 to 2022
$6.9M
RESEARCH TRAINING PROGRAM IN MOLECULAR VIROLOGYT32AI007471 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RAMIG, ROBERT FRANKLIN · 1996 to 2010
$2.6M
Translation Regulation by Enterovirus ProteinaseR56AI050237 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI LLOYD, RICHARD E · 2007 to 2007
$384k
NIAID NIH HHS AI50237NIAID NIH HHS R01 AI050237NIAID NIH HHS R56 AI050237NIAID NIH HHS T32 AI007471NIAID NIH HHS T32 AI07471
6 · The paper itself

Abstract

Viruses have adapted a broad range of unique mechanisms to modulate the cellular translational machinery to ensure viral translation at the expense of cellular protein synthesis. Many of these promote virus-specific translation by use of molecular tags on viral mRNA such as internal ribosome entry sites (IRES) and genome-linked viral proteins (VPg) that bind translation machinery components in unusual ways and promote RNA circularization. This review describes recent advances in understanding some of the mechanisms in which animal virus mRNAs gain an advantage over cellular transcripts, including new structural and biochemical insights into IRES function and novel proteins that function as alternate met-tRNA(i)(met) carriers in translation initiation. Comparisons between animal and plant virus mechanisms that promote translation of viral mRNAs are discussed.

Indexed as

Protein BiosynthesisAnimalsGene Expression Regulation, ViralHumansRibosomesViral ProteinsVirus DiseasesVirusesViral Proteinsanimal viruseIF2-independentinternal ribosome entryIREStranslation initiation

Identifiers

PMID22319551
PMCPMC3272495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.