ArticleFrontiers in microbiology2011
Bottlenecks in the transferability of antibiotic resistance from natural ecosystems to human bacterial pathogens.
Article in Frontiers in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- On the Low Abundance of Antibiotic Resistance Genes in Bacteriophage Genomes and Their Random Acquisition via Specialized Transduction.Genome biology and evolution · 2026Article
- Plastic leachates drive conjugative transfer of antibiotic resistance genes.Environmental science and ecotechnology · 2026Article
- Pharmacokinetic/pharmacodynamic relationships and development of resistance of enrofloxacin and cefquinome in combination therapy against Klebsiella pneumoniae in chicks.BMC veterinary research · 2026Article
- Antibiotic-degrading bacteria shape resistome dynamics and horizontal gene transfer potential in soils with contrasting properties.ISME communications · 2026Article
- Presence of Microorganisms in the Environment: One Health Approach.Microorganisms · 2025Review
- Effect of Mutations on the Evolution of Extended Spectrum β-lactamases (ESBL).The protein journal · 2025Review
- Detection of ESBL-producingFrontiers in microbiology · 2025Article
- Evidence of horizontal gene transfer and environmental selection impacting antibiotic resistance evolution in soil-dwelling Listeria.Nature communications · 2024Article
- State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review.Antibiotics (Basel, Switzerland) · 2022Review
- The global distribution and environmental drivers of the soil antibiotic resistome.Microbiome · 2022Article
- Evolutionary History and Strength of Selection Determine the Rate of Antibiotic Resistance Adaptation.Molecular biology and evolution · 2022Article
- Antibiotic Resistance in Bacteria-A Review.Antibiotics (Basel, Switzerland) · 2022Review
- Insights into the Antimicrobial Resistance Profile of a Next Generation ProbioticInternational journal of environmental research and public health · 2022Article
- Distribution, Diversity and Antibiotic Resistance of Pseudomonas spp. Isolated from the Water Dams in the North of Tunisia.Current microbiology · 2022Article
- Sequencing Depth Has a Stronger Effect than DNA Extraction on Soil Bacterial Richness Discovery.Biomolecules · 2022Article
- Evolutionary Pathways and Trajectories in Antibiotic Resistance.Clinical microbiology reviews · 2021Article
- Antimicrobial Resistance in Equine Reproduction.Animals : an open access journal from MDPI · 2021Review
- Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance.Nature ecology & evolution · 2021Article
- Directed Recovery and Molecular Characterization of Antibiotic Resistance Plasmids from Cheese Bacteria.International journal of molecular sciences · 2021Article
- Antibiotic Resistance: One Health One World Outlook.Frontiers in cellular and infection microbiology · 2021Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is generally accepted that resistance genes acquired by human pathogens through horizontal gene transfer originated in environmental, non-pathogenic bacteria. As a consequence, there is increasing concern on the roles that natural, non-clinical ecosystems, may play in the evolution of resistance. Recent studies have shown that the variability of determinants that can provide antibiotic resistance on their expression in a heterologous host is much larger than what is actually found in human pathogens, which implies the existence of bottlenecks modulating the transfer, spread, and stability of antibiotic resistance genes. In this review, the role that different factors such as founder effects, ecological connectivity, fitness costs, or second-order selection may have on the establishment of a specific resistance determinant in a population of bacterial pathogens is analyzed.
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