ArticleFrontiers in computational neuroscience2012
Mitral cell spike synchrony modulated by dendrodendritic synapse location.
Article in Frontiers in computational neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Decoding olfactory bulb output: A behavioral assessment of rate, synchrony, and respiratory phase coding.iScience · 2025Article
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.PLoS biology · 2024Article
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- Coherent olfactory bulb gamma oscillations arise from coupling independent columnar oscillators.Journal of neurophysiology · 2024Article
- Vasopressin differentially modulates the excitability of rat olfactory bulb neuron subtypes.Frontiers in neural circuits · 2024Article
- Axonal pathfinding during the development of the nervous system.Annals of the Child Neurology Society · 2023Review
- Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell-Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition.Frontiers in neural circuits · 2022Article
- Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors.Cell and tissue research · 2021Article
- Training deep neural density estimators to identify mechanistic models of neural dynamics.eLife · 2020Article
- Dendritic integration in olfactory bulb granule cells upon simultaneous multispine activation: Low thresholds for nonlocal spiking activity.PLoS biology · 2020Article
- Predicting brain organization with a computational model: 50-year perspective on lateral inhibition and oscillatory gating by dendrodendritic synapses.Journal of neurophysiology · 2020Review
- Rapid online learning and robust recall in a neuromorphic olfactory circuit.Nature machine intelligence · 2020Article
- Parallel odor processing by mitral and middle tufted cells in the olfactory bulb.Scientific reports · 2018Article
- Intraglomerular gap junctions enhance interglomerular synchrony in a sparsely connected olfactory bulb network.The Journal of physiology · 2017Article
- Exploring the significance of morphological diversity for cerebellar granule cell excitability.Scientific reports · 2017Article
- Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb.Scientific reports · 2016Article
- Biophysical constraints on lateral inhibition in the olfactory bulb.Journal of neurophysiology · 2016Article
- Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb.Frontiers in computational neuroscience · 2016Article
- Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
On their long lateral dendrites, mitral cells of the olfactory bulb form dendrodendritic synapses with large populations of granule cell interneurons. The mitral-granule cell microcircuit operating through these reciprocal synapses has been implicated in inducing synchrony between mitral cells. However, the specific mechanisms of mitral cell synchrony operating through this microcircuit are largely unknown and are complicated by the finding that distal inhibition on the lateral dendrites does not modulate mitral cell spikes. In order to gain insight into how this circuit synchronizes mitral cells within its spatial constraints, we built on a reduced circuit model of biophysically realistic multi-compartment mitral and granule cells to explore systematically the roles of dendrodendritic synapse location and mitral cell separation on synchrony. The simulations showed that mitral cells can synchronize when separated at arbitrary distances through a shared set of granule cells, but synchrony is optimally attained when shared granule cells form two balanced subsets, each subset clustered near to a soma of the mitral cell pairs. Another constraint for synchrony is that the input magnitude must be balanced. When adjusting the input magnitude driving a particular mitral cell relative to another, the mitral-granule cell circuit served to normalize spike rates of the mitral cells while inducing a phase shift or delay in the more weakly driven cell. This shift in phase is absent when the granule cells are removed from the circuit. Our results indicate that the specific distribution of dendrodendritic synaptic clusters is critical for optimal synchronization of mitral cell spikes in response to their odor input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.