ArticleFrontiers in integrative neuroscience2011
A novel, variable angle guide grid for neuronal activity studies.
Article in Frontiers in integrative neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 73 citations in OpenAlex.
- Using camera-guided electrode microdrive navigation for precise 3D targeting of macaque brain sites.PloS one · 2024Article
- Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation.Nature communications · 2022Article
- Using non-invasive neuroimaging to enhance the care, well-being and experimental outcomes of laboratory non-human primates (monkeys).NeuroImage · 2021Review
- Article
- Specialized areas for value updating and goal selection in the primate orbitofrontal cortex.eLife · 2015Article
- pyElectrode: an open-source tool using structural MRI for electrode positioning and neuron mapping.Journal of neuroscience methods · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSurgically implanted chambers with removable grids are routinely used for studying patterns of neuronal activity in primate brains; however, accessing target tissues is significantly constrained by standard grid designs. Typically, grids are configured with a series of guide holes drilled vertically, parallel to the walls of the chamber, thus targeted sites are limited to those in line vertically with one of the guide holes.
methodsBy using the three-dimensional modeling software, a novel grid was designed to reach the targeted sites far beyond the standard reach of the chamber. The grid was fabricated using conventional machining techniques and three-dimensional printing.
resultsA pilot study involving microinjection of the magnetic resonance (MR) contrast agent gadolinium into the discrete regions of interest (ROIs) in the temporal cortex of an awake, behaving monkey demonstrated the effectiveness of this new design of the guide grid. Using multiple different angles of approach, we were readily able to access 10 injection sites, which were up to 5 mm outside the traditional, orthogonal reach of the chamber.
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Registered trials
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