ArticleFrontiers in cellular neuroscience2011
GABA Not Only a Neurotransmitter: Osmotic Regulation by GABA(A)R Signaling.
Article in Frontiers in cellular neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Gamma-aminobutyric acid and glutamate system dysregulation in a small population of Egyptian children with autism spectrum disorder.Metabolic brain disease · 2025Article
- The Critical Role of the Shroom Family Proteins in Morphogenesis, Organogenesis and Disease.Phenomics (Cham, Switzerland) · 2024Review
- Local effect of allopregnanolone in rat ovarian steroidogenesis, follicular and corpora lutea development.Scientific reports · 2024Article
- Osmotic gradients and transretinal water flow-a quantitative elemental microanalytical study of frozen hydrated chick eyes.Frontiers in cellular neuroscience · 2022Article
- Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish.Communications biology · 2021Article
- GABAMolecular pharmacology · 2021Article
- Initial report of γ-aminobutyric acidergic locomotion regulatory system and its 3-mercaptopropionic acid-sensitivity in metamorphic juvenile of sea urchin, Hemicentrotus pulcherrimus.Scientific reports · 2020Article
- Overexpression of Shrm4 promotes proliferation and differentiation of neural stem cells through activation of GABA signaling pathway.Molecular and cellular biochemistry · 2020Article
- Detection of neural light-scattering activity in vivo: optical transmittance studies in the rat brain.NeuroImage · 2018Article
- Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.Journal of clinical and experimental hepatology · 2018Review
- Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.Molecular cancer research : MCR · 2018Article
- γ-Aminobutyric A receptor (GABA(A)R) regulates aquaporin 4 expression in the subependymal zone: relevance to neural precursors and water exchange.The Journal of biological chemistry · 2015Article
- Hypothalamic metabolic compartmentation during appetite regulation as revealed by magnetic resonance imaging and spectroscopy methods.Frontiers in neuroenergetics · 2013Article
- The Yin and Yen of GABA in Brain Development and Operation in Health and Disease.Frontiers in cellular neuroscience · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mature macroglia and almost all neural progenitor types express γ-aminobutyric (GABA) A receptors (GABA(A)Rs), whose activation by ambient or synaptic GABA, leads to influx or efflux of chloride (Cl(-)) depending on its electro-chemical gradient (E(Cl)). Since the flux of Cl(-) is indissolubly associated to that of osmotically obliged water, GABA(A)Rs regulate water movements by modulating ion gradients. In addition, since water movements also occur through specialized water channels and transporters, GABA(A)R signaling could affect the movement of water by regulating the function of the channels and transporters involved, thereby affecting not only the direction of the water fluxes but also their dynamics. We will here review recent observations indicating that in neural cells GABA(A)R-mediated osmotic regulation affects the cellular volume thereby activating multiple intracellular signaling mechanisms important for cell proliferation, maturation, and survival. In addition, we will discuss evidence that the osmotic regulation exerted by GABA may contribute to brain water homeostasis in physiological and in pathological conditions causing brain edema, in which the GABAergic transmission is often altered.
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