ArticleFrontiers in cellular neuroscience2011
Intracerebral transplantation for neurological disorders. Lessons from developmental, experimental, and clinical studies.
Article in Frontiers in cellular neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- The past, present, and future of traumatic spinal cord injury therapies: a review.Bone & joint open · 2022Article
- Impurity of stem cell graft by murine embryonic fibroblasts - implications for cell-based therapy of the central nervous system.Frontiers in cellular neuroscience · 2014Article
- Cell therapy for stroke: use of local astrocytes.Frontiers in cellular neuroscience · 2012Article
- Cell transplantation: relevance in understanding brain development and prospects in brain repair.Frontiers in cellular neuroscience · 2012Article
- Polyglutamine (polyQ) disorders: the chromatin connection.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of human pluripotent stem cells (PSCs) for cell therapy faces a number of challenges that are progressively answered by results from clinical trials and experimental research. Among these is the control of differentiation before transplantation and the prediction of cell fate after administration into the human brain, two aspects that condition both the safety and efficacy of the approach. For neurological disorders, this includes two steps: firstly, the identification of the optimal maturation stage for transplantation along the continuum that transforms PSCs into fully differentiated neural cell types, together with the derivation of robust protocols for large-scale production of biological products, and, secondly, the understanding of the effects of environmental cues and their possible interference with transplanted cells commitment. This review will firstly summarize our knowledge on developmental processes that have been applied to achieve robust in vitro differentiation of PSCs into neural progenitors. In a second part, we summarize results from experimental and clinical transplantation studies that help understanding the dialogue that establishes between transplanted cells and their host brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.